Catastrophic floods from breaching of natural dams on the Namche Barwa and Giala Peri play an important role in shaping high-mountain landforms in the eastern Himalayan syntaxis. However, there is limited knowledge of geomorphologic evidences and magnitude of outburst flooding in the Yarlung Tsangpo Grand Canyon. In this paper, geomorphic impacts of high-magnitude outburst floods (10(4)-10(6) m(3)/s) were analyzed using palaeoflood hydrology technology. Well-preserved 2018 Sedongpu (SDP) flood and 2000 Yigong (YG) flood sand bars are charactered by grey sands with parallel laminations, whereas megaflood geomorphic evidences in the Grand Canyon are dominated by massive slackwater deposits and lateral gravel bars. The palaeoflood events were dated to 4.3-2.4 ka, corresponding to the known Holocene megafloods in the lower Yarlung Tsangpo River. These flood ages are obviously younger than most of remnant lacustrine deposits during the late Pleistocene, but consistent with the ages in the top part of palaeolake and glacial moraines of the Namche Barwa. The chronological data help to confirm the highest probability phases of outburst floods from moraine-dammed lakes. The repeated megaflood peak discharges range from 0.5 to 1.1 x 10(6) m(3)/s, which are approximately 5-10 times greater than the maximum peak discharge of 2000 YG flood (9.5 x 10(4) m(3)/s) and 20-40 times than that of 2018 SDP flood (2.5 x 10(4) m(3)/s) in the Medog reach. Megaflood waters are always deepest (similar to 200 m) and fastest (similar to 50 m/s), which are at least twice times larger than 2000 YG flood. Higher shear stress (>3.3 kPa) and stream power per unit area (>168 kw/m(2)) occurred in narrower channel and sharp bend with higher velocity. Our model also predicts some potential erosion and deposition landscapes resulted from floodwaters routing through the Grand Canyon. These results address the geomorphic impacts of catastrophic flood events with magnitudes (10(4)-10(6) m(3)/s) in the Yarlung Tsangpo Grand Canyon. Our new palaeoflood geomorphologic evidences provide a key constraint on the age and magnitude of Holocene megafloods in the largest Himalayan River.