Traumatic events have lasting effects on mental and physical health,and significantly increase the incidence risk of psychiatric disorders.Post-traumatic stress disorder(PTSD)and depression are common psychopathological changes after traumatic stress.Studies have shown that the high comorbidity between PTSD and depression is the most common clinical complex syndrome after traumatic stress.This review systematically summarized PTSD and depression comorbidity studies from several aspects.In this paper,the clinical characteristics of PTSD and depression comorbidities were reviewed,suggesting that PTSD and depression comorbidities may have specific pathophysiological changes.Then the commonly used animal models of traumatic stress and the applications were introduced in the study of PTSD and depressive symptoms.Finally,clinical and basic research evidence of PTSD and depression comorbidity was outlined from several aspects,including brain circuit,neurotransmitter system,neuroendocrine,immune inflammation and neural plasticity,suggesting that PTSD and depressive symptoms comorbidity may have specific neurobiological basis.Existing studies support the need and importance to explore the pathological mechanisms of PTSD and depression comorbidities in depth and develop effective therapeutic targets for comorbidity.

创伤事件对心身健康产生持久的影响,显著增加多种精神障碍的发病风险。创伤后应激障碍(post-traumatic stress disorder,PTSD)和抑郁共病是创伤后最常见的复杂综合征。本文系统介绍了PTSD与抑郁共病研究:综述了PTSD与抑郁共病的临床特征并介绍了目前常用的PTSD动物模型在PTSD与抑郁症状研究中的应用,进而从脑环路、神经递质系统、神经内分泌、免疫炎性反应和神经可塑性等方面论证了PTSD与抑郁共病可能具有独特的神经生物学基础。这些证据支持深入地探讨PTSD与抑郁共病的病理机制,寻求共病治疗新靶点的必要性和重要性。

国家自然科学基金(82071517,U21A20364,31771217) 中国科学院心理研究所资助项目(E2CX4115CX)