A localized pallidal physiomarker in Meige syndrome
文献类型:期刊论文
作者 | Zhang, Bo4,5; Tian, Hong3; Yu, Yanbing3; Zhen, Xueke3; Zhang, Li3; Yuan, Yue3; Wang, Liang1,2 |
刊名 | FRONTIERS IN NEUROLOGY |
出版日期 | 2023-12-21 |
卷号 | 14页码:8 |
通讯作者邮箱 | twang@psych.ac.cn (liang wang) ; tianhng5185@126.com (hong tian) |
ISSN号 | 1664-2295 |
关键词 | Meige syndrome deep brain stimulation globus pallidus internus local field potentials theta oscillations |
DOI | 10.3389/fneur.2023.1286634 |
产权排序 | 4 |
文献子类 | 实证研究 |
英文摘要 | ObjectivesOscillatory patterns in local field potentials (LFPs) have been recognized as disease-specific physiomarkers, particularly in the context of Parkinson's disease and cervical dystonia. This characteristic oscillatory feature is currently employed in adaptive deep brain stimulation (aDBS). However, for other types of dystonia, especially Meige syndrome, a distinct physiomarker of this nature is yet to be identified.MethodsLocal field potentials were recorded during microelectrode-guided deep brain stimulation surgery from 28 patients with primary Meige syndrome. Before surgery, the severity of patients' motor syndrome were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale-Motor (BFMDRS-M). An instantaneous oscillation detection method was employed to identify true narrowband oscillations. Subsequently, a linear mixed effects model was utilized to examine the relationship between oscillatory activities (including power amplitude and burst duration) and symptom severity.ResultsThe focal peaks of "oscillatory activities" detected were predominantly concentrated in the narrow theta band (4-8 Hz), constituting 81.5% of the total detected oscillations in all recording sites near active DBS contacts in the globus pallidus internus (GPi). The linear mixed effects model revealed a positive correlation between the theta burst duration and the severity of preoperative motor impairment, but no correlation with postoperative motor scores. Additionally, there was no significant lateralization effect observed between the left and right GPi.ConclusionOur findings suggest that the exaggerated narrowband theta activity (mainly the burst duration) in the GPi is predictive of dystonia symptom severity and may be used as a physiomarker for optimized DBS target during surgery and adaptive DBS for the treatment of Meige syndrome. |
收录类别 | SCI |
WOS关键词 | DEEP BRAIN-STIMULATION ; FIELD POTENTIAL ACTIVITY ; INTERNUS ; DYSTONIA ; DISEASE |
资助项目 | National Natural Science Foundation of China10.13039/501100001809 |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:001135640800001 |
资助机构 | National Natural Science Foundation of China10.13039/501100001809 |
源URL | [http://ir.psych.ac.cn/handle/311026/46791] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Tian, Hong; Wang, Liang |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 3.China Japan Friendship Hosp, Dept Neurosurg, Beijing, Peoples R China 4.Zunyi Med Univ, Guizhou Key Lab Anesthesia & Organ Protect, Zunyi, Peoples R China 5.Zunyi Med Univ, Key Lab Brain Sci, Zunyi, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Bo,Tian, Hong,Yu, Yanbing,et al. A localized pallidal physiomarker in Meige syndrome[J]. FRONTIERS IN NEUROLOGY,2023,14:8. |
APA | Zhang, Bo.,Tian, Hong.,Yu, Yanbing.,Zhen, Xueke.,Zhang, Li.,...&Wang, Liang.(2023).A localized pallidal physiomarker in Meige syndrome.FRONTIERS IN NEUROLOGY,14,8. |
MLA | Zhang, Bo,et al."A localized pallidal physiomarker in Meige syndrome".FRONTIERS IN NEUROLOGY 14(2023):8. |
入库方式: OAI收割
来源:心理研究所
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