Overweight or Obesity Rate and Risk Factors in First-Episode and Drug-Na?ve Patients with Major Depressive Disorder with Comorbid Abnormal Lipid Metabolism: A Large-Scale Cross-Sectional Study
文献类型：期刊论文
| 作者 | Huang, Xiao4; Sun, Yuan3; Zhang, Xiangyang1,2
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| 刊名 | METABOLITES
 |
| 出版日期 | 2024 |
| 卷号 | 14期号:1页码:11 |
| 关键词 | overweight obesity major depressive disorder abnormal lipid metabolism rate |
| DOI | 10.3390/metabo14010026 |
| 通讯作者 | Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Overweight and obesity are frequent symptoms in patients with major depressive disorder (MDD) and abnormal lipid metabolism (ALM). There are no studies on the rate, risk factors, and underlying mechanisms of overweight/obesity in Chinese patients with MDD with comorbid ALM. The purpose of this study was to examine the rate of overweight/obesity and the associated risk factors among Chinese patients with MDD first-episode and drug-naive (FEDN) with comorbid ALM. This study was a cross-sectional research work. A total of 1718 patients were enrolled. Their clinical and laboratory data were obtained. All participants were assessed with the 17-item Hamilton Depression Rating Scale (HAMD), the Hamilton Anxiety Rating Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale. The plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triacylglycerols (TG), blood glucose concentrations, thyroid peroxidase antibody (A-TPO), thyoglubulin antibody (A-TG), thyroid-stimulating hormone (TSH), free thyoxine (FT4) and free triiodothyronine (FT3), and blood glucose concentrations were measured. ALM was identified as elevations in the plasma lipid values in this study. Of all the included subjects, the rate of ALM was 81.1%. The rate of obesity and overweight was 3.94% and 57.21%, respectively. Logistic regression analysis showed that TSH was the independent risk factor for overweight or obesity in MDD patients (adjusted OR = 1.158, 95%CI = 1.081-1.24, p < 0.001). The risk of developing overweight or obesity in MDD with ALM with comorbid TSH abnormalities was 2.176 times higher than those without TSH abnormalities (p < 0.001). Further linear regression showed TSH level (B = 0.1, t = 3.376, p = 0.001) and systolic blood pressure (B = 0.015, t = 2.351, p = 0.019) were risk factors for a higher body mass index (BMI). Our results demonstrate that being overweight is very frequent among patients with FEDN MDD with comorbid ALM but not obesity. TSH was the risk factor for overweight and obesity in MDD patients with comorbid ALM. |
| 收录类别 | SCI |
| WOS关键词 | CHINESE PATIENTS ; PREVALENCE ; DYSLIPIDEMIA ; EPIDEMIOLOGY ; ASSOCIATIONS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001152958300001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46935]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiangyang |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing 101408, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Peking Univ Third Hosp, Dept Pharm, Beijing 100191, Peoples R China 4.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xiao,Sun, Yuan,Zhang, Xiangyang. Overweight or Obesity Rate and Risk Factors in First-Episode and Drug-Na?ve Patients with Major Depressive Disorder with Comorbid Abnormal Lipid Metabolism: A Large-Scale Cross-Sectional Study[J]. METABOLITES,2024,14(1):11. |
| APA | Huang, Xiao,Sun, Yuan,&Zhang, Xiangyang.(2024).Overweight or Obesity Rate and Risk Factors in First-Episode and Drug-Na?ve Patients with Major Depressive Disorder with Comorbid Abnormal Lipid Metabolism: A Large-Scale Cross-Sectional Study.METABOLITES,14(1),11. |
| MLA | Huang, Xiao,et al."Overweight or Obesity Rate and Risk Factors in First-Episode and Drug-Na?ve Patients with Major Depressive Disorder with Comorbid Abnormal Lipid Metabolism: A Large-Scale Cross-Sectional Study".METABOLITES 14.1(2024):11. |
入库方式： OAI收割
来源：心理研究所
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