MICROMORPHOLOGY, PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF Isodon rugosus (Wail. ex Benth.) Codd
文献类型：期刊论文
| 作者 | Hameed, A.; Zafar, M.; Ahmad, M.; Sultana, S.; Akhter, M. S.; Zaman, W.; Saqib, S.; Ullah, F. |
| 刊名 | JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
 |
| 出版日期 | 2022 |
| 卷号 | 32期号:3页码:736-745 |
| ISSN号 | 1018-7081 |
| 关键词 | Isodon rugosus SEM LM phytochemicals antimicrobial cytotoxicity alpha-amylase inhibition |
| DOI | 10.36899/JAPS.2022.3.0475 |
| 文献子类 | Article |
| 英文摘要 | Isodon rugosus Wall. ex Benth (IR) is one of the ethnomedicinal important plants of Gilgit-Baltistan, Northern Pakistan. The present study aims to evaluate the micro-morphological features, phytochemical screening, and pharmacological potential of IR. SEM and LM were used as an identification tool. Five different solvents were used to prepare IR extracts. Phytochemical and antioxidant activities were determined calorimetrically. To investigate antidiabetic, alpha-amylase inhibition assay was adopted. Cytotoxicity was tested using a brine shrimp assay. Anti-leishmanial via MTT assay. Disc-diffusion assay was used for protein kinase inhibitory, antibacterial, and antifungal activities. Pollen was of monad, hexacolporate, and circular shape. Lophate sculpturing with outer exine pattern elevated on the rides. Seeds were oblong-ovate, small projected with smooth-rough, variously ridges/wrinkled sculpturing. Epidermis cells were irregular in shape with a slightly straight anticlinal wall. Stomata with diacytic, and unicellular glandular trichome were observed. The extracts were rich in phytochemicals, the maximum amount of phenolic and flavonoid contents was found in methanol extract (IRM) 89.76mg GAE/gm and 85.69mg QE/gm. All the extracts show substantial antioxidant activity but highest in IRM (DPPH IC50 44.51 mu g/ml, total antioxidant capacity 93.60 mg AAE/g, and total reduction power of 93.44 mg AAE/g). Potential antibacterial and antifungal activities were reported for IRM. Significant protein kinase, alpha-amylase inhibition, and cytotoxic activity were revealed. Dose-dependent cytotoxic activity was exposed against Leishmania tropica (LC50 11.16 mu g/mL). In conclusion, I. rugosus extracts have shown potential biological applications and should be subjected to further research work to develop further biomedical applications. |
| 学科主题 | Agriculture, Multidisciplinary ; Biology ; Veterinary Sciences |
| 电子版国际标准刊号 | 2309-8694 |
| 出版地 | LAHORE |
| WOS关键词 | ANTIOXIDANT ; EXTRACT ; IDENTIFICATION ; NANOPARTICLES |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| 出版者 | PAKISTAN AGRICULTURAL SCIENTISTS FORUM |
| WOS记录号 | WOS:000806392400014 |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28656]  |
| 专题 | 系统与进化植物学国家重点实验室 |
| 作者单位 | 1.[Zaman, W.] Yeungnam Univ, Dept Life Sci, Gyongsan 38541, Gyeongbuk, South Korea 2.[Hameed, A. 3.Zafar, M. 4.Ahmad, M. 5.Sultana, S.] Quaid I Azam Univ, Dept Plant Sci, Islamabad, Pakistan 6.[Akhter, M. S.] Univ Bahrain, Coll Sci, Dept Chem, Zallaq, Bahrain 7.[Saqib, S.] Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 8.[Saqib, S. 9.Ullah, F.] Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.[Ullah, F.] Chinese Acad Sci, Chengdu Inst Biol, CAS Key Lab Mt Ecol Restorat & Bioresource Utiliz, Chengdu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hameed, A.,Zafar, M.,Ahmad, M.,et al. MICROMORPHOLOGY, PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF Isodon rugosus (Wail. ex Benth.) Codd[J]. JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS,2022,32(3):736-745. |
| APA | Hameed, A..,Zafar, M..,Ahmad, M..,Sultana, S..,Akhter, M. S..,...&Ullah, F..(2022).MICROMORPHOLOGY, PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF Isodon rugosus (Wail. ex Benth.) Codd.JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS,32(3),736-745. |
| MLA | Hameed, A.,et al."MICROMORPHOLOGY, PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF Isodon rugosus (Wail. ex Benth.) Codd".JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS 32.3(2022):736-745. |
入库方式： OAI收割
来源：植物研究所
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