Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling
文献类型：期刊论文
| 作者 | Song, Chaoran; Lee, Chae Young; Lee, Hwa Pyoung; Hossain, Mohammad Amjad; Zhang, Zhiyun3; Kim, Soo-Yong; Song, Minkyung; Kim, Jong-Hoon; Cho, Jae Youl |
| 刊名 | PLANTS-BASEL
 |
| 出版日期 | 2022 |
| 卷号 | 11期号:18 |
| 关键词 | Malus baccata antioxidant anti-inflammatory aging |
| DOI | 10.3390/plants11182368 |
| 文献子类 | Article |
| 英文摘要 | Ultraviolet (UV) irradiation induces ROS production, which activates activator protein (AP)-1 and nuclear factor (NF)-kappa B signaling and downstream molecules, ultimately triggering the generation of matrix metalloproteinases (MMPs) and degradation of collagen. The aim of this study was to investigate the protective effect of methanol extract from Malus baccata (L.) Borkh (Mb-ME) against aging. DPPH and ABTS assays showed that Mb-ME had a significant antioxidant capacity. Flow cytometry results indicated that Mb-ME attenuated UVB and H2O2-stimulated apoptosis and reactive oxygen species (ROS) generation. RT-PCR analysis in HaCaT and HDF cells suggested that Mb-ME treatment blocked the expression of MMPs, COX-2, IL-1 beta, IL-6, HYALs, and p53 while promoting the levels of TGM1, FLG, HASs, Sirt1, and Col1A1. Mechanically, Mb-ME inhibited the phosphorylation of MAP kinases and NF-KB signaling. Overall, these results strongly suggest that Mb-ME can be developed as an antiaging therapy. |
| 学科主题 | Plant Sciences |
| 电子版国际标准刊号 | 2223-7747 |
| 出版地 | BASEL |
| WOS关键词 | CANCER CELLS ; PROMOTES ; STRESS ; DEGRADATION ; METASTASIS ; KERATINOCYTES ; RESISTANCE ; APOPTOSIS ; INJURY |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000856715000001 |
| 资助机构 | Medical Device Technology Development Program - Ministry of Trade, Industry, and Energy (MOTIE) [20008861] ; Korea Basic Science Institute (National Research Facilities and Equipment Center) - Ministry of Education, Republic of Korea [2020R1A6C101A191] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28772]  |
| 专题 | 系统与进化植物学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 2.Sungkyunkwan Univ, Coll Biotechnol & Bioengn, Dept Integrat Biotechnol, Suwon 16419, South Korea 3.Chonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea 4.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Chaoran,Lee, Chae Young,Lee, Hwa Pyoung,et al. Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling[J]. PLANTS-BASEL,2022,11(18). |
| APA | Song, Chaoran.,Lee, Chae Young.,Lee, Hwa Pyoung.,Hossain, Mohammad Amjad.,Zhang, Zhiyun.,...&Cho, Jae Youl.(2022).Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling.PLANTS-BASEL,11(18). |
| MLA | Song, Chaoran,et al."Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling".PLANTS-BASEL 11.18(2022). |
入库方式： OAI收割
来源：植物研究所
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