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The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponins

文献类型：期刊论文

作者Li, Yi; Tan, Chao; Li, Zihao; Guo, Jingzhe; Li, Song; Chen, Xin; Wang, Chen; Dai, Xiaokang; Yang, Huan; Song, Wei
刊名HORTICULTURE RESEARCH
出版日期2022
卷号9
ISSN号2662-6810
DOI10.1093/hr/uhac165
文献子类Article
英文摘要Diosgenin saponins isolated from Dioscorea species such as D. zingiberensis exhibit a broad spectrum of pharmacological activities. Diosgenin, the aglycone of diosgenin saponins, is an important starting material for the production of steroidal drugs. However, how plants produce diosgenin saponins and the origin and evolution of the diosgenin saponin biosynthetic pathway remain a mystery. Here we report a high-quality, 629-Mb genome of D. zingiberensis anchored on 10 chromosomes with 30322 protein-coding genes. We reveal that diosgenin is synthesized in leaves ('source'), then converted into diosgenin saponins, and finally transported to rhizomes ('sink') for storage in plants. By evaluating the distribution and evolutionary patterns of diosgenin saponins in Dioscorea species, we find that diosgenin saponin-containing may be an ancestral trait in Dioscorea and is selectively retained. The results of comparative genomic analysis indicate that tandem duplication coupled with a whole-genome duplication event provided key evolutionary resources for the diosgenin saponin biosynthetic pathway in the D. zingiberensis genome. Furthermore, comparative transcriptome and metabolite analysis among 13 Dioscorea species suggests that specific gene expression patterns of pathway genes promote the differential evolution of the diosgenin saponin biosynthetic pathway in Dioscorea species. Our study provides important insights and valuable resources for further understanding the biosynthesis, evolution, and utilization of plant specialized metabolites such as diosgenin saponins.
学科主题Plant Sciences ; Genetics & Heredity ; Horticulture
电子版国际标准刊号2052-7276
出版地CARY
WOS关键词STEROIDAL SAPONINS ; PHYLOGENETIC ANALYSIS ; PROVIDES INSIGHTS ; TOOL ; IDENTIFICATION ; PLANTS ; DIVERSITY ; SEQUENCE
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
出版者OXFORD UNIV PRESS INC
WOS记录号WOS:000922866000015
资助机构National Natural Science Foundation of China [30370152, 31270345, 31470388] ; USDA National Institute of Food and Agriculture [227700]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/28838]  
专题中科院植物分子生理学重点实验室
作者单位1.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
2.Shaoguan Univ, Henry Fok Coll Biol & Agr, Shaoguan 512005, Peoples R China
3.CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Trop Plant Resources & Sustainable Us, Xishuangbanna Trop Bot Garden, Kunming 650223, Yunnan, Peoples R China
4.Chinese Acad Sci, Ctr Integrat Conservat, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China
5.Grand Biosci, Beijing 102200, Peoples R China
6.Guangxi Univ, Coll Life Sci & Technol, Nanning 530004, Peoples R China
7.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan 430070, Peoples R China
8.Wuhan Univ, Coll Life Sci, State Key Lab Hybrid Rice, Wuhan 430072, Peoples R China
9.Smithsonian Inst, Dept Bot, Natl Museum Nat Hist, Washington, DC 20013 USA
10.Gang, David R.] Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA
推荐引用方式
GB/T 7714		 Li, Yi,Tan, Chao,Li, Zihao,et al. The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponins[J]. HORTICULTURE RESEARCH,2022,9.
APA Li, Yi.,Tan, Chao.,Li, Zihao.,Guo, Jingzhe.,Li, Song.,...&Li, Jiaru.(2022).The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponins.HORTICULTURE RESEARCH,9.
MLA Li, Yi,et al."The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponins".HORTICULTURE RESEARCH 9(2022).

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来源：植物研究所

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