Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9
文献类型：期刊论文
| 作者 | He, Yuqing2; Yu, Yingjun2; Wang, Xiling2; Qin, Yumei2; Su, Chen2; Wang, Lei2
|
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2022 |
| 卷号 | 13期号:1 |
| DOI | 10.1038/s41467-022-33568-3 |
| 文献子类 | Article |
| 英文摘要 | Circadian pace is modulated by light intensity, known as the Aschoff's rule, with largely unrevealed mechanisms. Here we report that photoreceptor CRY2 mediates blue light input to the circadian clock by directly interacting with clock core component PRR9 in blue light dependent manner. This physical interaction dually blocks the accessibility of PRR9 protein to its co-repressor TPL/TPRs and the resulting kinase PPKs. Notably, phosphorylation of PRR9 by PPKs is critical for its DNA binding and repressive activity, hence to ensure proper circadian speed. Given the labile nature of CRY2 in strong blue light, our findings provide a mechanistic explanation for Aschoff's rule in plants, i.e., blue light triggers CRY2 turnover in proportional to its intensity, which accordingly releasing PRR9 to fine tune circadian speed. Our findings not only reveal a network mediating light input into the circadian clock, but also unmask a mechanism by which the Arabidopsis circadian clock senses light intensity. |
| 学科主题 | Multidisciplinary Sciences |
| 出版地 | BERLIN |
| 电子版国际标准刊号 | 2041-1723 |
| WOS关键词 | TRANSCRIPTIONAL REPRESSION ; HYPOCOTYL ELONGATION ; ARABIDOPSIS ; CRYPTOCHROMES ; GROWTH ; CCA1 ; PHYTOCHROMES ; DEGRADATION ; PROTEINS ; TIMELESS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000864193100006 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206] ; National Natural Science Foundation of China [31770287] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28862]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Yuqing,Yu, Yingjun,Wang, Xiling,et al. Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9[J]. NATURE COMMUNICATIONS,2022,13(1). |
| APA | He, Yuqing,Yu, Yingjun,Wang, Xiling,Qin, Yumei,Su, Chen,&Wang, Lei.(2022).Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9.NATURE COMMUNICATIONS,13(1). |
| MLA | He, Yuqing,et al."Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9".NATURE COMMUNICATIONS 13.1(2022). |
入库方式： OAI收割
来源：植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。