Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis
文献类型：期刊论文
| 作者 | Wang, Boyu; Zhang, Honghong; Huai, Junling1; Peng, Fangyu; Wu, Jie; Lin, Rongcheng1; Fang, Xiaofeng |
| 刊名 | NATURE CHEMICAL BIOLOGY
 |
| 出版日期 | 2022 |
| 卷号 | 18期号:12 |
| ISSN号 | 1552-4450 |
| DOI | 10.1038/s41589-022-01196-z |
| 文献子类 | Article |
| 英文摘要 | Osmotic stress imposed by drought and high salinity inhibits plant growth and crop yield. However, our current knowledge on the mechanism by which plants sense osmotic stress is still limited. Here, we identify the transcriptional regulator SEUSS (SEU) as a key player in hyperosmotic stress response in Arabidopsis. SEU rapidly coalesces into liquid-like nuclear condensates when extracellular osmolarity increases. The intrinsically disordered region 1 (IDR1) of SEU is responsible for its condensation. IDR1 undergoes conformational changes to adopt more compact states after an increase in molecular crowding both in vitro and in cells, and two predicted alpha-helical peptides are required. SEU condensation is indispensable for osmotic stress tolerance, and loss of SEU dramatically compromises the expression of stress tolerance genes. Our work uncovers a critical role of biomolecular condensates in cellular stress perception and response and expands our understanding of the osmotic stress pathway. |
| 学科主题 | Biochemistry & Molecular Biology |
| 电子版国际标准刊号 | 1552-4469 |
| 出版地 | BERLIN |
| WOS关键词 | REGULATORY PROTEINS ; PHASE-SEPARATION ; GENE-EXPRESSION ; DYNAMICS ; FAMILY ; LEUNIG ; VOLUME |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| 出版者 | NATURE PORTFOLIO |
| WOS记录号 | WOS:000883236000001 |
| 资助机构 | National Natural Science Foundation of China [32161133001, 31800235, 32030009] ; Beijing Natural Science Foundation [JQ21020] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030205] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28912]  |
| 专题 | 中科院光生物学重点实验室 |
| 作者单位 | 1.Tsinghua Univ, Ctr Plant Biol, Sch Life Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Photobiol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Boyu,Zhang, Honghong,Huai, Junling,et al. Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis[J]. NATURE CHEMICAL BIOLOGY,2022,18(12). |
| APA | Wang, Boyu.,Zhang, Honghong.,Huai, Junling.,Peng, Fangyu.,Wu, Jie.,...&Fang, Xiaofeng.(2022).Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis.NATURE CHEMICAL BIOLOGY,18(12). |
| MLA | Wang, Boyu,et al."Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis".NATURE CHEMICAL BIOLOGY 18.12(2022). |
入库方式： OAI收割
来源：植物研究所
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