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Unraveling the Biosynthesis of Carvacrol in Different Tissues of Origanum vulgare

文献类型：期刊论文

作者Hao, Yuanpeng1,2; Guo, Xiaoqi1,2; Yang, Rui1,2; Yan, Yihao1,2; Sun, Meiyu2; Li, Hui2; Bai, Hongtong2; Cui, Hongxia2; Li, Jingyi4; Shi, Lei2
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2022
卷号23期号:21
关键词Origanum vulgare carvacrol tissue dependence SMRT WGCNA
DOI10.3390/ijms232113231
文献子类Article
英文摘要Origanum vulgare, belonging to the Lamiaceae family, is a principal culinary herb used worldwide which possesses great antioxidant and antibacterial properties corresponding to various volatile organic components (VOCs). However, the metabolite profiles and underlying biosynthesis mechanisms of elaborate tissues (stems, leaves, bracts, sepals, petals) of Origanum vulgare have seldom been reported. Here, solid-phase microextraction-gas chromatography/mass spectrometry results showed that Origanum vulgare 'Hot and Spicy' (O. vulgare 'HS') was extremely rich in carvacrol and had the tissue dependence characteristic. Moreover, a full-length transcriptome analysis revealed carvacrol biosynthesis and its tissue-specific expression patterns of 'upstream' MVA/MEP pathway genes and 'downstream' modifier genes of TPSs, CYPs, and SDRs. Furthermore, the systems biology method of modular organization analysis was applied to cluster 16,341 differently expressed genes into nine modules and to identify significant carvacrol- and peltate glandular trichome-correlated modules. In terms of these positive and negative modules, weighted gene co-expression network analysis results showed that carvacrol biosynthetic pathway genes are highly co-expressed with TF genes, such as ZIPs and bHLHs, indicating their involvement in regulating the biosynthesis of carvacrol. Our findings shed light on the tissue specificity of VOC accumulation in O. vulgare 'HS' and identified key candidate genes for carvacrol biosynthesis, which would allow metabolic engineering and breeding of Origanum cultivars.
学科主题Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
电子版国际标准刊号1422-0067
出版地BASEL
WOS关键词GERANYL DIPHOSPHATE SYNTHASE ; TRANSCRIPTION FACTOR ; GLANDULAR TRICHOMES ; TERPENE SYNTHASES ; ESSENTIAL OILS ; EXPRESSION ; ORGANIZATION ; SUPPRESSES ; METABOLISM ; DIVERSITY
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
出版者MDPI
WOS记录号WOS:000883971700001
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences [XDA26040306] ; NationalWild Plant Germplasm Resource Center
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/28863]  
专题中科院北方资源植物重点实验室
作者单位1.China Natl Bot Garden, Beijing 100093, Peoples R China
2.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Hao, Yuanpeng,Guo, Xiaoqi,Yang, Rui,et al. Unraveling the Biosynthesis of Carvacrol in Different Tissues of Origanum vulgare[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(21).
APA Hao, Yuanpeng.,Guo, Xiaoqi.,Yang, Rui.,Yan, Yihao.,Sun, Meiyu.,...&Shi, Lei.(2022).Unraveling the Biosynthesis of Carvacrol in Different Tissues of Origanum vulgare.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(21).
MLA Hao, Yuanpeng,et al."Unraveling the Biosynthesis of Carvacrol in Different Tissues of Origanum vulgare".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.21(2022).

入库方式： OAI收割

来源：植物研究所

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