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α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase

文献类型：期刊论文

作者Huang, Wenyuan; Guo, Xing; Wang, Chunyan; Alzhan, Amantay; Liu, Zhengan1,3; Ma, Xiaofeng; Shu, Qingyan1,3
刊名JOURNAL OF FUNCTIONAL FOODS
出版日期2022
卷号92
关键词Fatty acid synthase alpha-Linolenic acid Inhibitor Breast cancer cells Cell apoptosis
ISSN号1756-4646
DOI10.1016/j.jff.2022.105041
文献子类Article
英文摘要Fatty acid synthase (FASN) is an enzyme that synthesizes endogenous fatty acids. FASN overexpressed in various cancers, which indicates the involvement of FASN in cancer progression. alpha-Linolenic acid (ALA) is an omega-3 fatty acid with many biological activities, including anti-cancer effects. The aim of the present study was to investigate the inhibitory effect of ALA on fatty acid synthesis pathway and breast cancer cells apoptosis. We found FASN expression decreased significantly in ALA treated breast cancer cells. Compared with palmitic acid (PA), ALA reduced cell viability in a dose-dependent manner. ALA showed a higher affinity with the TE domain than PA. ALA induced breast cancer cells apoptosis, which effects were similar with the knockdown of FASN. In addition, ALA inhibited the invasion and metastasis, and arrested cell cycle in breast cancer cells. We propose a hypothesis that ALA could contribute to the treatment of human breast cancer by inhibiting FASN.
学科主题Food Science & Technology ; Nutrition & Dietetics
出版地AMSTERDAM
电子版国际标准刊号2214-9414
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; GROWTH ; FASN ; METABOLISM ; EXPRESSION ; AUTOPHAGY ; HER2
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000792001100001
出版者ELSEVIER
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences [XDA23080601] ; Fundamental Research Funds for the Central Universities [2012315] ; Youth Innovation Promotion Association, CAS
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/29063]  
专题中科院北方资源植物重点实验室
作者单位1.Univ Chinese Acad Sci, Coll Life Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Bot, Beijing Bot Garden, Beijing 100093, Peoples R China
3.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Wenyuan,Guo, Xing,Wang, Chunyan,et al. α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase[J]. JOURNAL OF FUNCTIONAL FOODS,2022,92.
APA Huang, Wenyuan.,Guo, Xing.,Wang, Chunyan.,Alzhan, Amantay.,Liu, Zhengan.,...&Shu, Qingyan.(2022).α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase.JOURNAL OF FUNCTIONAL FOODS,92.
MLA Huang, Wenyuan,et al."α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase".JOURNAL OF FUNCTIONAL FOODS 92(2022).

入库方式： OAI收割

来源：植物研究所

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