Delving the Role of the Ameliorative Effects of Caralluma tuberculata NEBr. (Apocynaceae) on Diabetes and Its Effect on the Organs Weight of Alloxan-Induced Adult Male Mice
文献类型：期刊论文
| 作者 | Batool, Saira1; Batool, Sajida1; Batool, Tahira2; Iram, Fatima1; Almas, Tahira1; Faizan, Muhammad1; Assad, Nasir2; Al-Sadoon, Mohammad Khalid3; Khan, Muhammad Nauman4,5; Ullah, Barkat4 |
| 刊名 | POLISH JOURNAL OF ENVIRONMENTAL STUDIES
 |
| 出版日期 | 2024 |
| 卷号 | 33期号:1页码:523-531 |
| 关键词 | alloxan ameliorative effects Caralluma tuberculata diabetes hypoglycemic effects |
| ISSN号 | 1230-1485 |
| DOI | 10.15244/pjoes/172080 |
| 通讯作者 | Batool, Saira(sairabatool1239@gmail.com) ; Khan, Muhammad Nauman(nomiflora@uop.edu.pk) |
| 英文摘要 | Caralluma tuberculata N.E.Br. is a naturally occurring plant that has been used for thousands of years for its health benefits. In the present study, the blood sugar lowering effect of C. tuberculata was investigated and compare with that of the diabetes drug metformin. The lyophilized extract of C. tuberculata was administered given to both non-diabetic and diabetic mice. Sixty mice were randomly divided into six groups. Blood glucose levels were measured after 24, 48, 72, and 96 h. The dose was administered orally after being dissolved in maize oil. Analysis of variance (ANOVA) and Tukey's post hoc test of SPSS were used to determine and compare the hypoglycemic effects of C. tuberculata extract and metformin at different time intervals. In diabetic mice administered C. tuberculata extract at a dosage of 200 mg/kg body weight, there was a significant (p<0.001) decrease in mean blood glucose level and a protective effect on organ weight. When the effects of the drug metformin (150 mg/kg body weight) were compared with those of crude plant extract C. tuberculata, the results indicated that metformin was less effective. C. tuberculate reduced blood glucose levels, and the effect was enhanced when it was combined with maize oil. CTE showed a protective effect against alloxan-induced increases in blood glucose levels and organ weight by increasing insulin production in an in vivo experiment. Therefore, CTE could be a promising pharmaceutical target for the treatment of diabetes. |
| WOS关键词 | ANTIOXIDANT |
| 资助项目 | King Saud University, Riyadh, Saudi Arabia[RSP2023R410] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001141527200029 |
| 出版者 | HARD |
| 资助机构 | King Saud University, Riyadh, Saudi Arabia |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/202196]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Batool, Saira; Khan, Muhammad Nauman |
| 作者单位 | 1.Univ Sargodha, Dept Zool, Sargodha 40100, Pakistan 2.Univ Sargodha, Inst Chem, Sargodha 40100, Pakistan 3.King Saud Univ, Coll Sci, Dept Zool, POB 2455, Riyadh 11451, Saudi Arabia 4.Islamia Coll Peshawar, Dept Bot, Peshawar 25120, Pakistan 5.Univ Peshawar, Univ Publ Sch UPS, Peshawar 25120, Pakistan 6.Batman Univ, Sason Vocat Sch, Dept Crop & Anim Prod, TR-72060 Batman, Turkiye 7.Quaid I Azam Univ, Dept Plant Sci, Islamabad 45320, Pakistan 8.Univ Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing, Peoples R China 9.Qarshi Brands Pvt Ltd, Prod & Proc Innovat Dept, Hattar 22610, Pakistan 10.Abdul Wali Khan Univ Mardan, Dept Bot, Mardan, Pakistan |
| 推荐引用方式 GB/T 7714 | Batool, Saira,Batool, Sajida,Batool, Tahira,et al. Delving the Role of the Ameliorative Effects of Caralluma tuberculata NEBr. (Apocynaceae) on Diabetes and Its Effect on the Organs Weight of Alloxan-Induced Adult Male Mice[J]. POLISH JOURNAL OF ENVIRONMENTAL STUDIES,2024,33(1):523-531. |
| APA | Batool, Saira.,Batool, Sajida.,Batool, Tahira.,Iram, Fatima.,Almas, Tahira.,...&Arif, Hafsa.(2024).Delving the Role of the Ameliorative Effects of Caralluma tuberculata NEBr. (Apocynaceae) on Diabetes and Its Effect on the Organs Weight of Alloxan-Induced Adult Male Mice.POLISH JOURNAL OF ENVIRONMENTAL STUDIES,33(1),523-531. |
| MLA | Batool, Saira,et al."Delving the Role of the Ameliorative Effects of Caralluma tuberculata NEBr. (Apocynaceae) on Diabetes and Its Effect on the Organs Weight of Alloxan-Induced Adult Male Mice".POLISH JOURNAL OF ENVIRONMENTAL STUDIES 33.1(2024):523-531. |
入库方式： OAI收割
来源：地理科学与资源研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。