Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window
文献类型：期刊论文
| 作者 | Ji, Yiming1; Bai, Xue3; Sun, Hongyan1; Wang, Luyao1; Gan, Chunyuan1; Jia, Lina1; Xu, Junjie1; Zhang, Wei1 ; Wang, Liang5; Xu, Yingchen6
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| 刊名 | ADVANCED HEALTHCARE MATERIALS
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| 出版日期 | 2023-11-27 |
| 页码 | 12 |
| ISSN号 | 2192-2640 |
| 关键词 | ferrofluid robots biocompatibility targeted therapy |
| DOI | 10.1002/adhm.202302395 |
| 通讯作者 | Feng, Lin(linfeng@buaa.edu.cn) |
| 英文摘要 | Ferrofluidic robots with excellent deformability and controllability have been intensively studied recently. However, most of these studies are in vitro and the use of ferrofluids for in vivo medicinal applications remains a big challenge. The application of ferrofluidic robots to the body requires the solution of many key problems. In this study, biocompatibility, controllability, and tumor-killing efficacy are considered when creating a ferrofluid-based millirobot for in vivo tumor-targeted therapy. For biocompatibility problems, corn oil is used specifically for the ferrofluid robot. In addition, a control system is built that enables a 3D magnetic drive to be implemented in complex biological media. Using the photothermal conversion property of 1064 nm, the ferrofluid robot can kill tumor cells in vitro; inhibit tumor volume, destroy the tumor interstitium, increase tumor cell apoptosis, and inhibit tumor cell proliferation in vivo. This study provides a reference for ferrofluid-based millirobots to achieve targeted therapies in vivo. In this study, biocompatibility, controllability, and tumor-killing efficacy are considered when creating a ferrofluid-based cross-scale robot for tumor-targeted therapy. For biocompatibility, corn oil is used specifically as the base-liquid. Furthermore, the robot can move in complex biological media. Using photothermal property under a 1064 nm laser, a ferrofluid robot can inhibit tumor volume in vivo.image |
| 资助项目 | National Key R&D Program of China ; Beijing Nova Program of Science and Technology[Z191100001119003] ; National Natural Science Foundation of China[52205584] ; [2019YFB1309700] |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:001108801900001 |
| 资助机构 | National Key R&D Program of China ; Beijing Nova Program of Science and Technology ; National Natural Science Foundation of China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/55086]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Feng, Lin |
| 作者单位 | 1.Beihang Univ, Sch Mech Engn & Automat, Beijing 100191, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100191, Peoples R China 3.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China 4.Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Capital Med Univ, Beijing Tongren Hosp, Dept Hematol, Beijing 100730, Peoples R China 6.Capital Med Univ, Beijing Tongren Hosp, Dept Gen Surg, Beijing 100730, Peoples R China 7.Capital Med Univ, Beijing Tongren Hosp, Dept Diagnost Ultrasound, Beijing 100730, Peoples R China 8.Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Yiming,Bai, Xue,Sun, Hongyan,et al. Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window[J]. ADVANCED HEALTHCARE MATERIALS,2023:12. |
| APA | Ji, Yiming.,Bai, Xue.,Sun, Hongyan.,Wang, Luyao.,Gan, Chunyuan.,...&Feng, Lin.(2023).Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window.ADVANCED HEALTHCARE MATERIALS,12. |
| MLA | Ji, Yiming,et al."Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window".ADVANCED HEALTHCARE MATERIALS (2023):12. |
入库方式： OAI收割
来源：自动化研究所
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