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The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology

文献类型：期刊论文

作者Wang, Yu-Jun1,5,6,7; Zan, Gui-Ying1,5,7; Xu, Cenglin4; Li, Xue-Ping5,7; Shu, Xuelian1,5,7; Yao, Song-Yu3; Xu, Xiao-Shan2; Qiu, Xiaoyun4; Chen, Yexiang8,9; Jin, Kai2
刊名NATURE COMMUNICATIONS
出版日期2023-11-30
卷号14期号:1页码:17
DOI10.1038/s41467-023-43636-x
通讯作者Xu, Lin(lxu@vip.163.com) ; Chen, Zhong(chenzhong@zju.edu.cn) ; Liu, Jing-Gen(jgliu@simm.ac.cn)
英文摘要Ample evidence has suggested the stress etiology of depression, but the underlying mechanism is not fully understood yet. Here, we report that chronic social defeat stress (CSDS) attenuates the excitatory output of the claustrum (CLA) to the prelimbic cortex (PL) through the dynorphin/kappa-opioid receptor (KOR) signaling, being critical for depression-related behaviors in male mice. The CSDS preferentially impairs the excitatory output from the CLA onto the parvalbumin (PV) of the PL, leading to PL micronetwork dysfunction by disinhibiting pyramidal neurons (PNs). Optogenetic activation or inhibition of this circuit suppresses or promotes depressive-like behaviors, which is reversed by chemogenetic inhibition or activation of the PV neurons. Notably, manipulating the dynorphin/KOR signaling in the CLA-PL projecting terminals controls depressive-like behaviors that is suppressed or promoted by optogenetic activation or inhibition of CLA-PL circuit. Thus, this study reveals both mechanism of the stress etiology of depression and possibly therapeutic interventions by targeting CLA-PL circuit. The stress etiology of depression remains elusive. Here, authors show that dynorphin/KOR signaling-mediated impairment of excitatory synaptic transmission from claustrum to prelimbic cortex PV interneurons contributes to stress-induced depression.
WOS关键词MEDIAL PREFRONTAL CORTEX ; GABAERGIC INTERNEURONS ; VISUAL-CORTEX ; BRAIN ; NEURONS ; MODULATION ; INHIBITION ; MOOD ; NEUROTRANSMISSION ; RESPONSES
资助项目National Natural Science Foundation of China (National Science Foundation of China)[2021ZD0202900] ; National Natural Science Foundation of China (National Science Foundation of China)[2021ZD0203500] ; Major Project of the Science and Technology Innovation 2030 of China[82030112] ; Major Project of the Science and Technology Innovation 2030 of China[81773710] ; Major Project of the Science and Technology Innovation 2030 of China[82273904] ; National Natural Science Foundation of China[20ZR1468200] ; National Natural Science Foundation of China[23ZR1474900] ; National Natural Science Foundation of China[NYKFKT2019015] ; Science and Technology Commission of Shanghai Municipality
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PORTFOLIO
WOS记录号WOS:001112447600028
源URL[http://119.78.100.183/handle/2S10ELR8/308499]  
专题中国科学院上海药物研究所
通讯作者Xu, Lin; Chen, Zhong; Liu, Jing-Gen
作者单位1.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
2.Kunming Inst Zool, Lab Learning & Memory, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
4.Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pro, Hangzhou, Peoples R China
5.Chinese Acad Sci, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
8.Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou 310053, Peoples R China
9.China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yu-Jun,Zan, Gui-Ying,Xu, Cenglin,et al. The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology[J]. NATURE COMMUNICATIONS,2023,14(1):17.
APA Wang, Yu-Jun.,Zan, Gui-Ying.,Xu, Cenglin.,Li, Xue-Ping.,Shu, Xuelian.,...&Liu, Jing-Gen.(2023).The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.NATURE COMMUNICATIONS,14(1),17.
MLA Wang, Yu-Jun,et al."The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology".NATURE COMMUNICATIONS 14.1(2023):17.

入库方式： OAI收割

来源：上海药物研究所

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