Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo
文献类型：期刊论文
| 作者 | Dai, Xiaolan2,3; Du, Zhenyun4,9; Jin, Can8; Tang, Bixi1; Chen, Xia; Jing, Xiaoqi; Shen, Yumei3; He, Fei4; Wang, Shunchun9; Li, Jia2,3,6,7
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| 刊名 | CARBOHYDRATE POLYMERS
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| 出版日期 | 2024-02-15 |
| 卷号 | 326页码:15 |
| ISSN号 | 0144-8617 |
| 关键词 | Fructan Hepatic fibrosis Hepatic stellate cells FAK/PI3K/AKT |
| DOI | 10.1016/j.carbpol.2023.121637 |
| 通讯作者 | Wang, Shunchun(shunchunwang@126.com) ; Li, Jia(Jli@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn) ; Zang, Yi(yzang@lglab.ac.cn) |
| 英文摘要 | Studies have shown that terrestrial acidic polysaccharides containing carboxyl groups and seaweed sulfated polysaccharides have strong potential in anti-liver fibrosis. However, there is no investigation on the anti-liver fibrosis of fructan, a ubiquitous natural polysaccharide. The present study aimed to understand the effect of fructan in ameliorating carbon tetrachloride (CCl4)-induced liver fibrosis in mice. Here, an inulin-like fructan ABWW from Achyranthes bidentata Bl. was characterized by fructose enzymatic hydrolysis, methylation analysis, ESI-MS, and NMR. It was composed of -> 2)-beta-d-Fruf-(1 -> and -> 2)-beta-d-Fruf-(1, 6 ->, terminated with -> 1)-alpha-d-Glcp and -> 2)-beta-d-Fruf residues. The biological studies showed that ABWW could improve liver damage and liver fibrosis induced by CCl4 in vivo and inhibit hepatic stellate cell (HSC) activation and migration in vitro. We further demonstrated that ABWW inhibited LX2 activation via suppressing the FAK/PI3K/AKT signaling pathway. Hence, ABWW might be a potential novel active compound for anti-fibrosis new drug development. |
| WOS关键词 | LIVER FIBROSIS ; TISSUE ; EXPRESSION ; FRUCTAN ; METALLOPROTEINASES ; REGENERATION ; INHIBITORS ; ADHESION ; KINASE ; MATRIX |
| 资助项目 | National Key Research and Development Program of China[2022YFA1303802] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[32271332] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[31870801] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[82130099] ; High-level New R D Institute[2019B090904008] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:001130332700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308508]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Shunchun; Li, Jia; Ding, Kan; Zang, Yi |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Drug Res Ctr, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China 5.Lingang Lab, Shanghai 201203, Peoples R China 6.ZhongShan Inst Drug Discovery, Zhongshan 528400, Guangdong, Peoples R China 7.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 8.Nanjing Univ Tradit Chinese Med, Nanjing 563003, Peoples R China 9.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Xiaolan,Du, Zhenyun,Jin, Can,et al. Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo[J]. CARBOHYDRATE POLYMERS,2024,326:15. |
| APA | Dai, Xiaolan.,Du, Zhenyun.,Jin, Can.,Tang, Bixi.,Chen, Xia.,...&Zang, Yi.(2024).Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo.CARBOHYDRATE POLYMERS,326,15. |
| MLA | Dai, Xiaolan,et al."Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo".CARBOHYDRATE POLYMERS 326(2024):15. |
入库方式： OAI收割
来源：上海药物研究所
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