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Electrochemical oxidative cyclization of N-allylamides for the synthesis of CF3-containing benzoxazines and oxazolines

文献类型：期刊论文

作者Li, Yutian1,3; Wang, Li1,3; Zhou, Shengbin1,3; He, Guoxue1,3; Zhou, Yu1,2,3
刊名RSC ADVANCES
出版日期2024-01-02
卷号14期号:1页码:154-159
DOI10.1039/d3ra07282g
通讯作者He, Guoxue(heguoxue@ucas.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn)
英文摘要The introduction of trifluoromethyl (-CF3) groups into compounds is a common synthetic strategy in organic chemistry. Commonly used methods for introducing trifluoromethyl groups are limited by harsh reaction conditions, low regioselectivity, or the need for excess reagents. In this study, a facile electrochemical oxidative and radical cascade cyclization of N-(2-vinylphenyl)amides for the synthesis of CF3-containing benzoxazines and oxazolines was obtained. This sustainable protocol features inexpensive and durable electrodes, a wide range of substrates, diverse functional group compatibility under transition-metal-free, external-oxidant-free, and additive-free conditions, and can be applied in an open environment.
WOS关键词OLEFINIC AMIDES ; POTENT ; INHIBITORS ; OXYTRIFLUOROMETHYLATION ; FLUORINE ; ALKENES
资助项目National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[91953108] ; National Natural Science Foundation of China[2022ZZ01015] ; National Natural Science Foundation of China[2022ZZ01012] ; National Natural Science Foundation of China[2022ZZ01019] ; Hangzhou institute for advanced study
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:001134779000001
源URL[http://119.78.100.183/handle/2S10ELR8/308538]  
专题中国科学院上海药物研究所
通讯作者He, Guoxue; Zhou, Yu
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yutian,Wang, Li,Zhou, Shengbin,et al. Electrochemical oxidative cyclization of N-allylamides for the synthesis of CF3-containing benzoxazines and oxazolines[J]. RSC ADVANCES,2024,14(1):154-159.
APA Li, Yutian,Wang, Li,Zhou, Shengbin,He, Guoxue,&Zhou, Yu.(2024).Electrochemical oxidative cyclization of N-allylamides for the synthesis of CF3-containing benzoxazines and oxazolines.RSC ADVANCES,14(1),154-159.
MLA Li, Yutian,et al."Electrochemical oxidative cyclization of N-allylamides for the synthesis of CF3-containing benzoxazines and oxazolines".RSC ADVANCES 14.1(2024):154-159.

入库方式： OAI收割

来源：上海药物研究所

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