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Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study

文献类型：期刊论文

作者Sun, Wen2; Tao, Lin2; Qian, Chen2; Xue, Peipei2; Tong, Xiankun1; Yang, Li1; Lu, Fang4; Wan, Hua3; Tao, Yingna2
刊名ARCHIVES OF MICROBIOLOGY
出版日期2024-02-01
卷号206期号:2页码:12
ISSN号0302-8933
关键词Human milk oligosaccharides Maternal characteristics Microbiota
DOI10.1007/s00203-023-03787-3
通讯作者Wan, Hua(drwanhua@hotmail.com) ; Tao, Yingna(TerainaTao@126.com)
英文摘要HMOs (Human milk oligosaccharide) has an impact on maternal and infant health. Colostrum samples of 70 breastfeeding women in China were collected and recorded clinical characteristics. The major oligosaccharides and microbiota were quantitated in colostrum. The concentration of fucosylated HMOs in primipara was higher than that of multipara (p = 0.030). The concentration of N-acetylated HMOs in vaginal delivery milk was less than that of cesarean (p = 0.038). Non-fucosylated HMOs of breastfeeding women were less than that of breast pump (p = 0.038). Meanwhile, the concentration of LNT was positively correlated with Lactobacillus (r = 0.250, p = 0.037). DS-LNT was negatively correlated with Staphylococcus (r = - 0.240, p = 0.045). There was a positive correlation of Streptococcus with LNFP II (r = 0.314, p = 0.011) and 3-SL (r = 0.322, p = 0.009). In addition, there was a negative correlation between 2'-FL and 3-FL (r = - 0.465, p = 0.001). There was a positive correlation between LNT and LNnT (r = 0.778, p = 0.001). Therefore, the concentration of HMOs is related to number of deliveries, delivery mode, lactation mode and perinatal antibiotic. The concentration of HMOs is related to Lactobacillus, Streptococcus and Streptococcus in colostrum. In addition, there are connections between different oligosaccharides in content. The study protocol was also registered in the ClinicalTrails.gov (ChiCTR2200064454) (Oct. 2022).
WOS关键词HEALTHY WOMEN ; QUANTITATION ; PROFILES ; GLYCOME ; GROWTH
资助项目Shanghai Hongkou District Health Committee Meeting Project
WOS研究方向Microbiology
语种英语
出版者SPRINGER
WOS记录号WOS:001137948100001
源URL[http://119.78.100.183/handle/2S10ELR8/308547]  
专题中国科学院上海药物研究所
通讯作者Wan, Hua; Tao, Yingna
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China
2.Tongji Univ, Dept Tradit Chinese Med, Shanghai Peoples Hosp 4, Shanghai 200434, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Dept Breast, Shuguang Hosp, Shanghai 201203, Peoples R China
4.Tongji Univ, Dept Nephrol, Shanghai Peoples Hosp 4, Shanghai, 200434, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Wen,Tao, Lin,Qian, Chen,et al. Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study[J]. ARCHIVES OF MICROBIOLOGY,2024,206(2):12.
APA Sun, Wen.,Tao, Lin.,Qian, Chen.,Xue, Peipei.,Tong, Xiankun.,...&Tao, Yingna.(2024).Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study.ARCHIVES OF MICROBIOLOGY,206(2),12.
MLA Sun, Wen,et al."Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study".ARCHIVES OF MICROBIOLOGY 206.2(2024):12.

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来源：上海药物研究所

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