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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

文献类型：期刊论文

作者Chang, Baisong3; Chen, Jie3; Bao, Jiasheng3; Sun, Taolei3; Cheng, Zhen1,2
刊名CHEMICAL REVIEWS
出版日期2023-11-22
卷号123期号:24页码:13966-14037
ISSN号0009-2665
DOI10.1021/acs.chemrev.3c00401
通讯作者Chang, Baisong(chang@whut.edu.cn) ; Sun, Taolei(suntl@whut.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn)
英文摘要Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is of great value for biomedical applications. Academic evidence of fluorescence imaging indicates that virtually all imaging metrics (sensitivity, resolution, and penetration depths) are improved when progressing into longer wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000-1700 nm) window. Although the emission wavelength of probes does matter, it is not clear whether the guideline of "the longer the wavelength, the better the imaging effect" is still suitable for developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization of large deep tissues. For studies dealing with bioimaging of tiny biological architectures or dynamic physiopathological activities, the prerequisite is rigorous planning of long-wavelength phosphorescence, being aware of the cooperative contribution of long wavelengths and long lifetimes for improving the spatiotemporal resolution, penetration depth, and sensitivity of bioimaging. In this Review, emerging molecular engineering methods of room-temperature phosphorescence are discussed through the lens of photophysical mechanisms. We highlight the roles of phosphorescence with emission from visible to NIR-II windows toward bioapplications. To appreciate such advances, challenges and prospects in rapidly growing studies of room-temperature phosphorescence are described.
WOS关键词AGGREGATION-INDUCED EMISSION ; ENDOPLASMIC-RETICULUM STRESS ; MOLYBDENUM CLUSTER COMPLEXES ; METAL-ORGANIC FRAMEWORKS ; LAYERED DOUBLE HYDROXIDE ; TRIPLET EXCITED-STATES ; NIR-II WINDOW ; PHOTODYNAMIC THERAPY ; CARBON DOTS ; IRIDIUM(III) COMPLEXES
资助项目Science and Technology Commission of Shanghai Municipality[52373307] ; Science and Technology Commission of Shanghai Municipality[U2267221] ; National Natural Science Foundation of China[2021CFB344] ; Natural Science Foundation of Hubei Province, China ; Young Top-notch Talent Cultivation Program of Hubei Province, China[TM202301H003] ; Shanghai Municipal Science and Technology Major Project[SYS202205] ; Shandong Laboratory Program
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001133464000001
源URL[http://119.78.100.183/handle/2S10ELR8/308553]  
专题新药研究国家重点实验室
通讯作者Chang, Baisong; Sun, Taolei; Cheng, Zhen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Shandong, Peoples R China
3.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Chang, Baisong,Chen, Jie,Bao, Jiasheng,et al. Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window[J]. CHEMICAL REVIEWS,2023,123(24):13966-14037.
APA Chang, Baisong,Chen, Jie,Bao, Jiasheng,Sun, Taolei,&Cheng, Zhen.(2023).Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window.CHEMICAL REVIEWS,123(24),13966-14037.
MLA Chang, Baisong,et al."Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window".CHEMICAL REVIEWS 123.24(2023):13966-14037.

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来源：上海药物研究所

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