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Limonoids and alkaloids from Tetradium austrosinense (Hand.-Mazz.) TG Hartley

文献类型：期刊论文

作者Han, Feng1,2; Yao, Jia-Ying3,4; Tan, Jun-Jie1; Qin, Nan1,5; Jiang, Yu-Xia1,2; Jiang, Kun1; He, Shi-Jun4,7; Tan, Chang-Heng1,2,6
刊名FITOTERAPIA
出版日期2024
卷号172页码:5
ISSN号0367-326X
关键词Rutaceae Tetradium austrosinense Limonoids Alkaloids TDDFT-ECD calculation Anti-inflammation
DOI10.1016/j.fitote.2023.105759
通讯作者He, Shi-Jun(heshijun@shutcm.edu.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn)
英文摘要A pair of new enantiomeric indolopyridoquinazoline-type alkaloids, (+)-1,7S,8R- and (-)-1,7R,8S-trihydroxyr-utaecarpine (3a and 3b), and a new limonoid-tyrosamine hybrid, austrosinin (8), along with six known alkaloids and limonoids, were isolated from the stems with leaves of Tetradium austrosinense. Their structures were elucidated on the basis of analysis of MS, NMR, ECD and time-dependent density functional theory-based electronic circular dichroism (TDDFT-ECD) calculations, as well as proposed biosynthetic pathway. An antiinflammatory bioassay in vitro showed 8 had significant immunosuppressive effect against the production of pro-inflammatory cytokine TNF-alpha in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
资助项目National Science &Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China[2019ZX09201001]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:001129791100001
源URL[http://119.78.100.183/handle/2S10ELR8/308556]  
专题中国科学院上海药物研究所
通讯作者He, Shi-Jun; Tan, Chang-Heng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Jiangxi Univ Chinese Med, Grad Sch, Nanchang 330004, Jiangxi, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
7.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Han, Feng,Yao, Jia-Ying,Tan, Jun-Jie,et al. Limonoids and alkaloids from Tetradium austrosinense (Hand.-Mazz.) TG Hartley[J]. FITOTERAPIA,2024,172:5.
APA Han, Feng.,Yao, Jia-Ying.,Tan, Jun-Jie.,Qin, Nan.,Jiang, Yu-Xia.,...&Tan, Chang-Heng.(2024).Limonoids and alkaloids from Tetradium austrosinense (Hand.-Mazz.) TG Hartley.FITOTERAPIA,172,5.
MLA Han, Feng,et al."Limonoids and alkaloids from Tetradium austrosinense (Hand.-Mazz.) TG Hartley".FITOTERAPIA 172(2024):5.

入库方式： OAI收割

来源：上海药物研究所

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