Unraveling the complex roles of macrophages in obese adipose tissue: an overview
文献类型：期刊论文
| 作者 | Peng, Chang2,3; Chen, Jun4,5; Wu, Rui1; Jiang, Haowen2; Li, Jia1,2
|
| 刊名 | FRONTIERS OF MEDICINE
 |
| 出版日期 | 2024-01-02 |
| 页码 | 32 |
| ISSN号 | 2095-0217 |
| 关键词 | obesity inflammation adipose tissue macrophages adipose tissue homeostasis |
| DOI | 10.1007/s11684-023-1033-7 |
| 通讯作者 | Jiang, Haowen(haowenjiang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn) |
| 英文摘要 | Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic diseases. The activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects, inducing insulin resistance through increased inflammation, impaired thermogenesis, and adipose tissue fibrosis. Meanwhile, adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis, facilitating the clearance of dead adipocytes, and promoting mitochondrial transfer. Exploring the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic interventions. Recently, the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell technology. In this review, we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity, as well as explore the potential of drug delivery systems targeting macrophages, aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases. |
| WOS关键词 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; ALTERNATIVELY ACTIVATED MACROPHAGES ; TARGETED DRUG-DELIVERY ; DIET-INDUCED OBESITY ; TNF-ALPHA ANTIBODY ; N-TERMINAL KINASE ; CD4(+) T-CELLS ; INSULIN-RESISTANCE ; MITOCHONDRIAL TRANSFER ; CLODRONATE LIPOSOMES |
| 资助项目 | National Natural Science Foundation of China[32000525] ; Shanghai Municipal Science and Technology Major Project, Shanghai Municipal Science and Technology Major Project[TM202101H001] ; Shanghai Municipal Science and Technology Major Project, Shanghai Municipal Science and Technology Major Project[LG202103-03-01] |
| WOS研究方向 | Oncology ; Research & Experimental Medicine |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:001134972400003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308562]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jiang, Haowen; Li, Jia |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Res Inst Stomatol, Coll Stomatol,Sch Med,Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China 5.Shanghai Jiao Tong Univ, Coll Stomat,Shanghai Peoples Hosp 9, Shanghai Engn Res Ctr Adv Dent Technol & Mat, Natl Clin Res Ctr Oral Dis,Dept Prosthodont,Sch Me, Shanghai 200011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Chang,Chen, Jun,Wu, Rui,et al. Unraveling the complex roles of macrophages in obese adipose tissue: an overview[J]. FRONTIERS OF MEDICINE,2024:32. |
| APA | Peng, Chang,Chen, Jun,Wu, Rui,Jiang, Haowen,&Li, Jia.(2024).Unraveling the complex roles of macrophages in obese adipose tissue: an overview.FRONTIERS OF MEDICINE,32. |
| MLA | Peng, Chang,et al."Unraveling the complex roles of macrophages in obese adipose tissue: an overview".FRONTIERS OF MEDICINE (2024):32. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。