Revisiting the Role of Valeric Acid in Manipulating Ulcerative Colitis
文献类型：期刊论文
| 作者 | Liu, Moting3,4; Zhang, Yao2; Liu, Jia1 ; Xiang, Caigui3,4; Lu, Qiukai3,4; Lu, Huimin3,4; Yang, Tao3,4; Wang, Xiaohan3,4; Zhang, Qingli1; Fan, Chen4
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| 刊名 | INFLAMMATORY BOWEL DISEASES
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| 出版日期 | 2024-01-11 |
| 页码 | 12 |
| ISSN号 | 1078-0998 |
| 关键词 | ulcerative colitis macrophages gut microbes scfas valeric acid |
| DOI | 10.1093/ibd/izad187 |
| 通讯作者 | Li, Heng(cpuliheng@126.com) |
| 英文摘要 | Background Ulcerative colitis (UC) is characterized by a complicated interaction between mucosal inflammation, epithelial dysfunction, abnormal activation of innate immune responses, and gut microbiota dysbiosis. Though valeric acid (VA), one type of short-chain fatty acids (SCFAs), has been identified in other inflammatory disorders and cancer development, the pathological role of VA and underlying mechanism of VA in UC remain under further investigation.Methods Studies of human clinical specimens and experimental colitis models were conducted to confirm the pathological manifestations of the level of SCFAs from human fecal samples and murine colonic homogenates. Valeric acid-intervened murine colitis and a macrophage adoptive transfer were applied to identify the underlying mechanisms.Results In line with gut microbiota dysfunction in UC, alteration of SCFAs from gut microbes were identified in human UC patients and dextran sodium sulfate -induced murine colitis models. Notably, VA was consistently negatively related to the disease severity of UC, the population of monocytes, and the level of interluekin-6. Moreover, VA treatment showed direct suppressive effects on lipopolysaccharides (LPS)-activated human peripheral blood mononuclear cells and murine macrophages in the dependent manner of upregulation of GPR41 and GPR43. Therapeutically, replenishment of VA or adoptive transfer with VA-modulated macrophages showed resistance to dextran sodium sulfate-driven murine colitis though modulating the production of inflammatory cytokine interleukin-6.Conclusions In summary, the research uncovered the pathological role of VA in modulating the activation of macrophages in UC and suggested that VA might be a potential effective agent for UC patients. The study collectively indicated that valeric acid (VA) was consistently negatively related to the disease severity of UC, and hypofunction of macrophage driven by VA impeded the progression of UC. |
| WOS关键词 | CHAIN FATTY-ACIDS ; INFLAMMATORY-BOWEL-DISEASE ; GUT MICROBIOTA ; METABOLITES |
| 资助项目 | National Natural Science Foundation of China[82173822] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS INC |
| WOS记录号 | WOS:001140113900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308568]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Heng |
| 作者单位 | 1.Chinese Acad Sci, Inst Technol Serv Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Gastroenterol, Shanghai 200025, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Moting,Zhang, Yao,Liu, Jia,et al. Revisiting the Role of Valeric Acid in Manipulating Ulcerative Colitis[J]. INFLAMMATORY BOWEL DISEASES,2024:12. |
| APA | Liu, Moting.,Zhang, Yao.,Liu, Jia.,Xiang, Caigui.,Lu, Qiukai.,...&Tang, Wei.(2024).Revisiting the Role of Valeric Acid in Manipulating Ulcerative Colitis.INFLAMMATORY BOWEL DISEASES,12. |
| MLA | Liu, Moting,et al."Revisiting the Role of Valeric Acid in Manipulating Ulcerative Colitis".INFLAMMATORY BOWEL DISEASES (2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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