Exosomes: New Insights into the Pathogenesis of Metabolic Syndrome
文献类型：期刊论文
| 作者 | Wang, Ning2; Li, Jing2 ; Hu, Zixuan2; Ngowi, Ebenezeri Erasto2,3,4,5; Yan, Baolong1; Qiao, Aijun2,3
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| 刊名 | BIOLOGY-BASEL
 |
| 出版日期 | 2023-12-01 |
| 卷号 | 12期号:12页码:14 |
| 关键词 | exosome biogeneration function metabolic syndrome |
| DOI | 10.3390/biology12121480 |
| 通讯作者 | Qiao, Aijun(qiaoaijun@simm.ac.cn) |
| 英文摘要 | Exosomes are a subtype of extracellular vesicles (EVs) with a diameter of 30 similar to 150 nm (averaging similar to 100 nm) that are primarily produced through the endosomal pathway, and carry various components such as lipids, proteins, RNA, and other small molecular substances. Exosomes can mediate intercellular communication through the bioactive substances they carry, thus participating in different physiological activities. Metabolic syndrome (MS) is a disease caused by disturbances in the body ' s metabolism, mainly including insulin resistance (IR), diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), hyperlipidemia, and atherosclerosis (AS). Recent studies have shown that exosomes are closely related to the occurrence and development of MS. Exosomes can act as messengers to mediate signaling transductions between metabolic cells in the organism and play a bidirectional regulatory role in the MS process. This paper mainly reviews the components, biogenesis, biological functions and potential applications of exosomes, and exosomes involved in the pathogenesis of MS as well as their clinical significance in MS diagnosis. |
| WOS关键词 | INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; EXTRACELLULAR VESICLES ; PROSTATE-CANCER ; SHEDDING LIGHT ; MICRORNAS ; BIOLOGY ; CELLS ; CERAMIDE ; THERAPY |
| 资助项目 | National Natural Science Foundation of China |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001132025800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308651]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qiao, Aijun |
| 作者单位 | 1.Wenzhou Med Univ, Sch Basic Med Sci, Wenzhou 325035, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 5.Dar Es Salaam Univ, Coll Educ, Dept Biol Sci, Dar Es Salaam 2329, Tanzania |
| 推荐引用方式 GB/T 7714 | Wang, Ning,Li, Jing,Hu, Zixuan,et al. Exosomes: New Insights into the Pathogenesis of Metabolic Syndrome[J]. BIOLOGY-BASEL,2023,12(12):14. |
| APA | Wang, Ning,Li, Jing,Hu, Zixuan,Ngowi, Ebenezeri Erasto,Yan, Baolong,&Qiao, Aijun.(2023).Exosomes: New Insights into the Pathogenesis of Metabolic Syndrome.BIOLOGY-BASEL,12(12),14. |
| MLA | Wang, Ning,et al."Exosomes: New Insights into the Pathogenesis of Metabolic Syndrome".BIOLOGY-BASEL 12.12(2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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