Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
文献类型：期刊论文
| 作者 | Ma, Xiao-yu1,2,3; Chen, Man-man1,2,3; Meng, Ling-hua1,2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2024-01-04 |
| 页码 | 10 |
| 关键词 | CDNs 2'3'-cGAMP cGAS-STING tumor microenvironment ENPP1 TREX1 |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-023-01210-7 |
| 通讯作者 | Meng, Ling-hua(lhmeng@simm.ac.cn) |
| 英文摘要 | Cytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, which is activated upon binding to dsDNA to synthesize the crucial second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP) that in turn triggers stimulator of interferon genes (STING) signaling. The canonical role of cGAS-cGAMP-STING pathway is essential for innate immunity and viral defense. Recent emerging evidence indicates that 2'3'-cGAMP plays an important role in cancer progression via cell autonomous and non-autonomous mechanisms. Beyond its role as an intracellular messenger to activate STING signaling in tumor cells, 2'3'-cGAMP also serves as an immunotransmitter produced by cancer cells to modulate the functions of non-tumor cells especially immune cells in the tumor microenvironment by activating STING signaling. In this review, we summarize the synthesis, transmission, and degradation of 2'3'-cGAMP as well as the dual functions of 2'3'-cGAMP in a STING-dependent manner. Additionally, we discuss the potential therapeutic strategies that harness the cGAMP-mediated antitumor response for cancer therapy. |
| WOS关键词 | DOUBLE-STRANDED DNA ; CGAS-STING PATHWAY ; CHROMOSOMAL INSTABILITY ; CYCLIC DINUCLEOTIDES ; EXTRACELLULAR CGAMP ; ANTITUMOR IMMUNITY ; BYSTANDER CELLS ; ACTIVATION ; MACROPHAGES ; METASTASIS |
| 资助项目 | State Key Laboratory of Chemical Biology |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001136032900001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308660]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Meng, Ling-hua |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiao-yu,Chen, Man-man,Meng, Ling-hua. Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression[J]. ACTA PHARMACOLOGICA SINICA,2024:10. |
| APA | Ma, Xiao-yu,Chen, Man-man,&Meng, Ling-hua.(2024).Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression.ACTA PHARMACOLOGICA SINICA,10. |
| MLA | Ma, Xiao-yu,et al."Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression".ACTA PHARMACOLOGICA SINICA (2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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