Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity
文献类型：期刊论文
| 作者 | Wu, Yao2,3; Li, Yongping1; Hu, Zixin7; Li, Yuan3; Zhang, Shixuan5,6; Bao, Xinyue2; Zhou, Yu3 ; Gao, Yuan2; Li, Yaping3,4; Zhang, Zhiwen2
|
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2024-01-18 |
| 页码 | 14 |
| ISSN号 | 0935-9648 |
| 关键词 | antitumor responses bioinspired lipoprotein extracellular matrix pomalidomide tumor retention |
| DOI | 10.1002/adma.202310982 |
| 通讯作者 | Gao, Yuan(yuan_gao@fudan.edu.cn) ; Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn) |
| 英文摘要 | The immunomodulatory effects of many therapeutic agents are significantly challenged by their insufficient delivery efficiency and short retention time in tumors. Regarding the distinctively upregulated fibronectin (FN1) and tenascin C (TNC) in tumor stroma, herein a protease-activated FN1 and/or TNC binding peptide (FTF) is designed and an extracellular matrix (ECM)-trapped bioinspired lipoprotein (BL) (FTF-BL-CP) is proposed that can be preferentially captured by the TNC and/or FN1 for tumor retention, and then be responsively dissociated from the matrix to potentiate the antitumor immunity. The FTF-BL-CP treatment produces a 6.96-, 9.24-, 6.72-, 7.32-, and 6.73-fold increase of CD3+CD8+ T cells and their interferon-gamma-, granzyme B-, perforin-, and Ki67-expressing subtypes versus the negative control, thereby profoundly eliciting the antitumor immunity. In orthotopic and lung metastatic breast cancer models, FTF-BL-CP produces notable therapeutic benefits of retarding tumor growth, extending survivals, and inhibiting lung metastasis. Therefore, this ECM-trapping strategy provides an encouraging possibility of prolonging tumor retention to potentiate the antitumor immunity for anticancer immunotherapy. Regarding the distinctively upregulated fibronectin (FN1) and tenascin C (TNC) in tumor stroma, a protease-sensitive TNC and FN1-binding peptide (FTF) is designed and an extracellular matrix-trapped bioinspired lipoprotein (BL) system (FTF-BL-CP) is proposed that can preferentially bind to the FN1 and TNC in tumors to prolong their retention capacity, thereby profoundly potentiating the antitumor immunity and producing notable therapeutic benefits .image |
| WOS关键词 | REMODELS TUMOR ; T-CELL ; CANCER ; HETEROGENEITY ; INFILTRATION ; PROGRESSION ; STRATEGIES ; SURVIVAL |
| 资助项目 | National Key Research and Development Program of China ; Shanghai Advanced Research Institute, Chinese Academy of Sciences, China ; National Natural Science Foundation of China[32271461] ; National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[81972392] ; National Natural Science Foundation of China[82272769] ; National Comprehensive Reform Pilot Zone for the Development of Traditional Chinese Medicine in Pudong New Area[PDZY-2021-0817] ; Department of Breast Surgery at Shanghai Pudong Hospital, Fudan University Pudong Medical Center (Shanghai, China) ; Clinical Trial Ethics Committee of Shanghai Pudong Hospital[2022-RS-XM-01] ; Shanghai Experimental Animal Center, Chinese Academy of Sciences[67077] ; [2023YFE0104300] ; [2022YFC2304303] ; [2022YFC3401400] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:001144336600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308675]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gao, Yuan; Li, Yaping; Zhang, Zhiwen |
| 作者单位 | 1.Fudan Univ, Shanghai Pudong Hosp, Dept Breast Surg, Pudong Med Ctr, Shanghai 201399, Peoples R China 2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264005, Shandong, Peoples R China 5.Fudan Univ, Human Phenome Inst, Shanghai 200433, Peoples R China 6.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China 7.Fudan Univ, Artificial Intelligence Innovat & Incubat Inst, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yao,Li, Yongping,Hu, Zixin,et al. Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity[J]. ADVANCED MATERIALS,2024:14. |
| APA | Wu, Yao.,Li, Yongping.,Hu, Zixin.,Li, Yuan.,Zhang, Shixuan.,...&Zhang, Zhiwen.(2024).Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity.ADVANCED MATERIALS,14. |
| MLA | Wu, Yao,et al."Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity".ADVANCED MATERIALS (2024):14. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。