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Bioorthogonal chemistry mediated cell engineering for advanced cell and cell-derived vesicle therapies: Principles, progresses, and remaining challenges

文献类型：期刊论文

作者Pan, Chao1,6; Jiang, Xiuxian1,6; Liu, Chang1,6; Wei, Junchao1,4; Wang, Yang1,4; Yang, Canyu1,3; Gan, Yong1,2,3,4,5,6
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2024-01-15
卷号480页码:19
ISSN号1385-8947
关键词Bioorthogonal chemistry Metabolic labelling Cell therapy Surface engineering Cell-derived vesicle
DOI10.1016/j.cej.2023.148120
通讯作者Gan, Yong(ygan@simm.ac.cn)
英文摘要In the past few decades, cell and cell-derived vesicle therapies have experienced rapid development and played an increasingly important role in treating diverse diseases. Surface engineering can outfit cells and cell-derived vesicles with extrinsic functions to enhance efficacy. Nevertheless, traditional genetic, chemical, and physical cell engineering methods have limitations such as low efficiency, lack of specificity, and safety concerns, leading to a growing preference for bioorthogonal approaches. In light of its high efficiency, selectivity, and biocompatibility, bioorthogonal chemistry has been extensively employed in developing targeted or multifunctional delivery systems through direct bioorthogonal conjugation with target sites as well as coupling with nanoparticles, biomolecules, and chemotherapeutic drugs. In this review, we first introduce basic principles of bioorthogonal chemistry, including the main labeling pathways and typical bioorthogonal reactions. Then, we shed light on the recent breakthroughs in exploiting bioorthogonal chemistry to decorate multiple cells (stem cells, immune cells, cancer cells, islet beta cells, and bacteria) and cell-derived vesicles for elevated target or combination therapy. Finally, we provide insights into the current limitations and future prospects of bioorthogonal chemistry in biomedical applications. This summary provides a panoramic view of bioorthogonal chemistry in cell and cell derived vesicle therapies and inspires researchers to explore further applications of bioorthogonal chemistry in new indications.
WOS关键词ANTIGEN-PRESENTING CELLS ; PROTEINS ; FUNCTIONALIZATION ; CYCLOADDITION ; NANOPARTICLES ; PHOSPHOLIPIDS ; BIOSYNTHESIS ; MAGNETOSOMES ; LIGATION ; SYSTEMS
资助项目National Science Fund of Distinguished Young Scholars[82025032] ; Open Competition to Select the Best Candidates Key Technology Program for Nucleic Acid Drugs of National Center of Technology Innovation for Biopharmaceuticals[NCTIB2022HS01006] ; Key Research Program of Chinese Academy of Sciences[ZDBS-ZRKJZ-TLC005] ; China Postdoctoral Science Foundation[2021M703350] ; Shanghai Post-doctoral Excellence Program[2021427]
WOS研究方向Engineering
语种英语
出版者ELSEVIER SCIENCE SA
WOS记录号WOS:001142474400001
源URL[http://119.78.100.183/handle/2S10ELR8/308781]  
专题中国科学院上海药物研究所
通讯作者Gan, Yong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China
2.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
4.Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210046, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Pan, Chao,Jiang, Xiuxian,Liu, Chang,et al. Bioorthogonal chemistry mediated cell engineering for advanced cell and cell-derived vesicle therapies: Principles, progresses, and remaining challenges[J]. CHEMICAL ENGINEERING JOURNAL,2024,480:19.
APA Pan, Chao.,Jiang, Xiuxian.,Liu, Chang.,Wei, Junchao.,Wang, Yang.,...&Gan, Yong.(2024).Bioorthogonal chemistry mediated cell engineering for advanced cell and cell-derived vesicle therapies: Principles, progresses, and remaining challenges.CHEMICAL ENGINEERING JOURNAL,480,19.
MLA Pan, Chao,et al."Bioorthogonal chemistry mediated cell engineering for advanced cell and cell-derived vesicle therapies: Principles, progresses, and remaining challenges".CHEMICAL ENGINEERING JOURNAL 480(2024):19.

入库方式： OAI收割

来源：上海药物研究所

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