Role of F-box proteins in human upper gastrointestinal tumors
文献类型：期刊论文
| 作者 | Zhang, Che1,3,4; Pan, Guangzhao4; Qin, Jiang-Jiang2,3,4,5 |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
 |
| 出版日期 | 2024 |
| 卷号 | 1879期号:1页码:16 |
| ISSN号 | 0304-419X |
| 关键词 | F-box protein Upper gastrointestinal cancer E3 ubiquitin ligase Ubiquitin |
| DOI | 10.1016/j.bbcan.2023.189035 |
| 通讯作者 | Qin, Jiang-Jiang(jqin@ucas.ac.cn) |
| 英文摘要 | Protein ubiquitination and degradation is an essential physiological process in almost all organisms. As the key participants in this process, the E3 ubiquitin ligases have been widely studied and recognized. F-box proteins, a crucial component of E3 ubiquitin ligases that regulates diverse biological functions, including cell differentia-tion, proliferation, migration, and apoptosis by facilitating the degradation of substrate proteins. Currently, there is an increasing focus on studying the role of F-box proteins in cancer. In this review, we present a comprehensive overview of the significant contributions of F-box proteins to the development of upper gastrointestinal tumors, highlighting their dual roles as both carcinogens and tumor suppressors. We delve into the molecular mecha-nisms underlying the involvement of F-box proteins in upper gastrointestinal tumors, exploring their interactions with specific substrates and their cross-talks with other key signaling pathways. Furthermore, we discuss the implications of F-box proteins in radiotherapy resistance in the upper gastrointestinal tract, emphasizing their potential as clinical therapeutic and prognostic targets. Overall, this review provides an up-to-date understanding of the intricate involvement of F-box proteins in human upper gastrointestinal tumors, offering valuable insights for the identification of prognostic markers and the development of targeted therapeutic strategies. |
| WOS关键词 | SQUAMOUS-CELL CARCINOMA ; GASTRIC-CANCER CELLS ; TO-MESENCHYMAL TRANSITION ; SCF UBIQUITIN-LIGASE ; KINASE-ASSOCIATED PROTEIN-2 ; DETERMINES POOR-PROGNOSIS ; CYCLIN D1 ; GENE-EXPRESSION ; UP-REGULATION ; DECREASED EXPRESSION |
| 资助项目 | Zhejiang Province[LR21H280001] ; Key Laboratory of Preven-tion, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhe-jiang Province[2022E10021] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Oncology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001134874000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308787]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qin, Jiang-Jiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China 3.UCAS, Hangzhou Inst Adv Study, Sch Mol Med, Hangzhou 310024, Peoples R China 4.Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China 5.Key Lab Prevent Diag & Therapy Upper Gastrointesti, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Che,Pan, Guangzhao,Qin, Jiang-Jiang. Role of F-box proteins in human upper gastrointestinal tumors[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,2024,1879(1):16. |
| APA | Zhang, Che,Pan, Guangzhao,&Qin, Jiang-Jiang.(2024).Role of F-box proteins in human upper gastrointestinal tumors.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,1879(1),16. |
| MLA | Zhang, Che,et al."Role of F-box proteins in human upper gastrointestinal tumors".BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1879.1(2024):16. |
入库方式： OAI收割
来源：上海药物研究所
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