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Multi-omics reveals the attenuation of metabolic cardiomyopathy in mice by alkaloids in extracts from Clausena lansium (Lour.) via the transition of gastrointestinal microbiota to an alternative homeostasis

文献类型：期刊论文

作者Shu, Chi3,4; Huang, Jian-yuan2,4; Yang, Gui-yuan1; Xing, Na4,5; Zhao, Yong1; Chanda, Francis4,5,6; Chaurembo, Abdallah Iddy4,5,6; Lin, Han-bin2,4,5,6,7; Lin, Kai-xuan1,8
刊名JOURNAL OF FUNCTIONAL FOODS
出版日期2024
卷号112页码:15
ISSN号1756-4646
关键词Alkaloids Duncaniella Girinimbine Norleucine Metabolic disorders Wampee
DOI10.1016/j.jff.2023.105946
通讯作者Lin, Han-bin(linhanbin@zidd.ac.cn) ; Lin, Kai-xuan(zszyyywk@126.com)
英文摘要Wampee has various biological functions, and the current study assesses its protective effects against metabolic cardiomyopathy (CMP) by focusing on gastrointestinal microbiota. The composition of wampee extract (WE) was determined, and mice were subjected to CMP model induction before handled with WE. WE improved heart function, reduced intestine permeability, and suppressed inflammation, and the function was attributed to alkaloids including girinimbine and stachydrine. The CMP model and WE had little influence on the alpha diversity, while CMP model changed the beta-diversity of mice microbiota. Duncaniella, Ruminococcus, Aspergillus, and Penicillium were positively correlated with the progression of metabolic CMP, while Muribaculum, Paramuribaculum, and Prevotella were negatively correlated, the abundance of which were restored by WE. The changes in microbes increased function enrichment in pathways related to immune responses and produced cardio-protective metabolites such as norleucine. WE induced a new homeostasis in the GI microbiota of CMP mice, thereby attenuating metabolic CMP.
WOS关键词HEART-FAILURE ; GUT-MICROBIOTA ; OBESITY ; SIGNAL
资助项目National Natural Science Foundation of China[82100391] ; High-level New R & D Institute of Department of Science and Technology of Guangdong Province[2019B090904008] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003]
WOS研究方向Food Science & Technology ; Nutrition & Dietetics
语种英语
出版者ELSEVIER
WOS记录号WOS:001149389400001
源URL[http://119.78.100.183/handle/2S10ELR8/308921]  
专题新药研究国家重点实验室
通讯作者Lin, Han-bin; Lin, Kai-xuan
作者单位1.Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Dept Cardiol, Zhongshan, Guangdong, Peoples R China
2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
3.Shenyang Agr Univ, Coll Food Sci, Shenyang, Liaoning, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Guangdong, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Lab Chem, Shanghai 201203, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Chinese Acad Sci, Sch Pharmaceut Sci,Southern Med Univ, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
8.Zhongshan Hosp Tradit Chinese Med, Dept Cardiol, 3 Kangxin Rd, Zhongshan 528400, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Shu, Chi,Huang, Jian-yuan,Yang, Gui-yuan,et al. Multi-omics reveals the attenuation of metabolic cardiomyopathy in mice by alkaloids in extracts from Clausena lansium (Lour.) via the transition of gastrointestinal microbiota to an alternative homeostasis[J]. JOURNAL OF FUNCTIONAL FOODS,2024,112:15.
APA Shu, Chi.,Huang, Jian-yuan.,Yang, Gui-yuan.,Xing, Na.,Zhao, Yong.,...&Lin, Kai-xuan.(2024).Multi-omics reveals the attenuation of metabolic cardiomyopathy in mice by alkaloids in extracts from Clausena lansium (Lour.) via the transition of gastrointestinal microbiota to an alternative homeostasis.JOURNAL OF FUNCTIONAL FOODS,112,15.
MLA Shu, Chi,et al."Multi-omics reveals the attenuation of metabolic cardiomyopathy in mice by alkaloids in extracts from Clausena lansium (Lour.) via the transition of gastrointestinal microbiota to an alternative homeostasis".JOURNAL OF FUNCTIONAL FOODS 112(2024):15.

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来源：上海药物研究所

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