Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity
文献类型：期刊论文
| 作者 | Yu, Jun-dong2; Wang, Jing-Yi2; Liu, Jia-yuan1,3; Xu, Ye-chun1,3 ; Zhang, Xue4; Du, Jun4; Wu, Xiao-hong4; Chen, Liang4; Wu, Ying-Chun2; Li, Yi-Ming2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2024-03-01 |
| 卷号 | 173页码:14 |
| ISSN号 | 0367-326X |
| 关键词 | diterpene glycosides Rubus Chingii Hu PDE5A inhibitory activity ent-labdane |
| DOI | 10.1016/j.fitote.2023.105780 |
| 通讯作者 | Chen, Liang(Clark.chen@amway.com) ; Wu, Ying-Chun(wuyingchun2013@163.com) ; Li, Yi-Ming(ymlius@163.com) |
| 英文摘要 | In this study, 16 new ent-labdane-type diterpene glycosides, designated as goshonosides J1-J16 (1-16), along with nine previously known diterpene glycosides (17-25) were extracted from the fruits of Rubus chingii Hu. The structures of goshonosides J1-J16 were elucidated using various analytical techniques, such as nuclear magnetic resonance, electron capture detector ECD, high-resolution electrospray ionization mass spectrometry HREIMS, single-crystal X-ray diffraction, and hydrolysis. Furthermore, the isolates' efficacy in inhibiting the activity of phosphodiesterase type 5 A was evaluated. Goshonosides J1, J2, and G effectively inhibited the activity of the aforementioned enzyme (IC50 values: 6.15 +/- 1.76, 3.27 +/- 0.65, and 9.61 +/- 2.36 mu M, respectively). Our findings highlight the remarkable structural diversity of bioactive compounds in R. chingii Hu and offer insights into the use of this shrub. |
| WOS关键词 | FRUITS ; EXTRACT ; CONSTITUENTS ; LEAVES |
| 资助项目 | Foundation for Innovative Research Groups of the National Natural Science Foun ; National Natural Science Foundation of China[81973458] ; Fujiang Guo, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001146817100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308933]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Liang; Wu, Ying-Chun; Li, Yi-Ming |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Amway Shanghai Innovat & Sci Co Ltd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Jun-dong,Wang, Jing-Yi,Liu, Jia-yuan,et al. Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity[J]. FITOTERAPIA,2024,173:14. |
| APA | Yu, Jun-dong.,Wang, Jing-Yi.,Liu, Jia-yuan.,Xu, Ye-chun.,Zhang, Xue.,...&Li, Yi-Ming.(2024).Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity.FITOTERAPIA,173,14. |
| MLA | Yu, Jun-dong,et al."Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity".FITOTERAPIA 173(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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