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Supramolecular Nano-Grid Platform to Load and Deliver Liposomes and Exosomes

文献类型：期刊论文

作者Li, Jing1,2; Ma, Wuzhen1,2; Ren, Xiaohong1; Guo, Tao1; Yang, Boyang3; Huang, Chenxi1,2; Xiong, Ting1,3; Guo, Yuhua1,2; Li, Zeru1,4; Wang, Siwen1,2
刊名SMALL STRUCTURES
出版日期2024-01-30
页码10
关键词boronated organic framework exosomes liposomes nano-grid particles stimuli-responsive
DOI10.1002/sstr.202300487
通讯作者Wang, Shujun(wangshujun@syphu.edu.cn) ; Wu, Li(wuli@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要In general, carriers are designed to deliver pharmaceutical (featuring small drug-molecules) and biopharmaceutical (featuring large-molecule drugs, e.g., antibodies, proteins, etc.) active ingredients and platform that is capable of transporting nanoparticles is rare. Herein, the fabrication of a supramolecular carrier with a nano-grid structure for the entrapment of liposomes and exosomes is reported. The nano-grid particles (NGP) are made of cyclodextrins as elementary units which are widely used to load drugs through host-guest inclusion complexes, whilst its secondary structure further formed the NGP tertiary architectures, enabling the entrapment of nanoparticles. The NGP features stimuli responsiveness, tunable surface charge, and good biocompatibility. The entrapped liposomes in NGP present enhanced distribution in lungs and extended duration of action in mice. And elongated release profiles for over 14 days is obtained for exosomes-making one-of-its-kind unique platform to load and deliver nanoparticles. A supramolecular carrier with nano-grid structure is designed using cyclodextrins as primary units, which is featured with stimuli responsiveness, tunable surface charge, and biocompatibility. Nanoparticles of artificial liposomes and exosomes were successfully anchored in the nano voids within nano-grid, providing liposomes extended duration and enhanced distribution in lungs in mice, and exosomes extremely elongated release profiles to weeks.image (c) 2024 WILEY-VCH GmbH
WOS关键词METAL-ORGANIC FRAMEWORKS ; BACTERIOPHAGES ; MICROBUBBLES
资助项目National Natural Science Foundation of China ; National Science and Technology Major Projects for National Key R&D Program of China[2020YFE0201700] ; Shanghai Advanced Research Institute, Chinese Academy of Sciences ; [82273863]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:001152363700001
源URL[http://119.78.100.183/handle/2S10ELR8/308945]  
专题中国科学院上海药物研究所
通讯作者Wang, Shujun; Wu, Li; Zhang, Jiwen
作者单位1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
3.Shenyang Pharmaceut Univ, Coll Pharm, Shenyang 110016, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210046, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jing,Ma, Wuzhen,Ren, Xiaohong,et al. Supramolecular Nano-Grid Platform to Load and Deliver Liposomes and Exosomes[J]. SMALL STRUCTURES,2024:10.
APA Li, Jing.,Ma, Wuzhen.,Ren, Xiaohong.,Guo, Tao.,Yang, Boyang.,...&Zhang, Jiwen.(2024).Supramolecular Nano-Grid Platform to Load and Deliver Liposomes and Exosomes.SMALL STRUCTURES,10.
MLA Li, Jing,et al."Supramolecular Nano-Grid Platform to Load and Deliver Liposomes and Exosomes".SMALL STRUCTURES (2024):10.

入库方式： OAI收割

来源：上海药物研究所

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