NIR-II fluorescence imaging without intended excitation light
文献类型：期刊论文
| 作者 | Ji, Aiyan1,5; Lou, Hongyue1; Li, Jiafeng1; Hao, Yimeng5; Wei, Xiaonan1; Wu, Yibin1; Zhao, Weili5; Chen, Hao1,2,4; Cheng, Zhen1,2,3,5 |
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2024-01-30 |
| 页码 | 10 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d3sc06165e |
| 通讯作者 | Zhao, Weili(zhaoweili@fudan.edu.cn) ; Chen, Hao(haoc@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Nowadays, second near-infrared window (NIR-II) dyes are almost excited by laser diodes, but none of the white light (400-700 nm) excited NIR-II imaging has been studied because of the lack of suitable optical probes. Herein, a novel blue-shifted NIR-II dye, TPA-TQT, has been selected for use in multi-wavelength white light emitting diode (LED) excited NIR-II imaging. This white LED barely caused photo-quenching of the dyes, especially indocyanine green (ICG), whereas the ICG's brightness decreased by 90% under continuous 808 nm laser irradiation. Compared to single-wavelength LED, multi-wavelength LED showed a lower background and similar signal-to-background ratios. This system provided high image resolution to identify blood vessels (103 mu m), lymphatic capillaries (129.8 mu m), and to monitor hindlimb ischemia-reperfusion and lymphatic inflammation. Furthermore, white LED excited NIR-II fluorescence imaging-guided surgery (FIGS) was successfully performed in 4T1 tumor-bearing mice. Impressively, the lighting LED-based NIR-II FIGS was found to clearly delineate small lesions of metastatic tumors of about similar to 350 mu m diameter and further was able to guide surgical removal. Overall, multi-wavelength LED-based NIR-II imaging is a promising imaging strategy for tumor delineation and other biomedical applications. Multi-wavelength LED excited NIR-II imaging strategy based on a blue-shifted dye-TPA-TQT. |
| WOS关键词 | FLUOROPHORES |
| 资助项目 | Science and Technology Commission of Shanghai Municipality[U2267221] ; Science and Technology Commission of Shanghai Municipality[82071976] ; National Natural Science Foundation of China[TM202301H003] ; Shanghai Municipal Science and Technology Major Project[SYS202205] ; Shandong Laboratory Program[CSTB2023TIAD-STX0006] ; Science and Technology Innovation Key R&D Program of Chongqing[YDZX20233100004032001] ; Science and Technology Commission of Shanghai Municipality[2023YFA1800804] ; Science and Technology Commission of Shanghai Municipality[2021ZD0203900] ; National Key Research and Development Program of China[LG-QS-202206-01] ; Lingang Laboratory |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:001151971600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308957]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Weili; Chen, Hao; Cheng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 5.Fudan Univ, Sch Pharm, Dept Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Aiyan,Lou, Hongyue,Li, Jiafeng,et al. NIR-II fluorescence imaging without intended excitation light[J]. CHEMICAL SCIENCE,2024:10. |
| APA | Ji, Aiyan.,Lou, Hongyue.,Li, Jiafeng.,Hao, Yimeng.,Wei, Xiaonan.,...&Cheng, Zhen.(2024).NIR-II fluorescence imaging without intended excitation light.CHEMICAL SCIENCE,10. |
| MLA | Ji, Aiyan,et al."NIR-II fluorescence imaging without intended excitation light".CHEMICAL SCIENCE (2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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