Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy
文献类型：期刊论文
| 作者 | Kang, Xuejia3,7; Huang, Yongzhuo4,5 ; Wang, Huiyuan5; Jadhav, Sanika6; Yue, Zongliang1; Tiwari, Amit K.2; Babu, R. Jayachandra7
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| 刊名 | PHARMACEUTICS
 |
| 出版日期 | 2024 |
| 卷号 | 16期号:1页码:28 |
| 关键词 | tumor-associated macrophage suppressive immune environment tumor proliferation and metastasis nanomedicine targeted delivery systems |
| DOI | 10.3390/pharmaceutics16010061 |
| 通讯作者 | Babu, R. Jayachandra(ramapjb@auburn.edu) |
| 英文摘要 | The tumor microenvironment (TME) is pivotal in tumor growth and metastasis, aligning with the "Seed and Soil" theory. Within the TME, tumor-associated macrophages (TAMs) play a central role, profoundly influencing tumor progression. Strategies targeting TAMs have surfaced as potential therapeutic avenues, encompassing interventions to block TAM recruitment, eliminate TAMs, reprogram M2 TAMs, or bolster their phagocytic capabilities via specific pathways. Nanomaterials including inorganic materials, organic materials for small molecules and large molecules stand at the forefront, presenting significant opportunities for precise targeting and modulation of TAMs to enhance therapeutic efficacy in cancer treatment. This review provides an overview of the progress in designing nanoparticles for interacting with and influencing the TAMs as a significant strategy in cancer therapy. This comprehensive review presents the role of TAMs in the TME and various targeting strategies as a promising frontier in the ever-evolving field of cancer therapy. The current trends and challenges associated with TAM-based therapy in cancer are presented. |
| WOS关键词 | MHC CLASS-I ; RECEPTOR TYROSINE KINASES ; MESENCHYMAL STEM-CELLS ; GROWTH-FACTOR-BETA ; T-CELL ; TGF-BETA ; ANTITUMOR IMMUNOTHERAPY ; LIPID NANOPARTICLES ; INHIBITORY RECEPTOR ; ANTI-PD-1 ANTIBODY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001150967300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308966]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Babu, R. Jayachandra |
| 作者单位 | 1.Auburn Univ, Harrison Sch Pharm, Dept Hlth Outcome & Res Policy, Auburn, AL 36849 USA 2.Univ Arkansas Med Sci, Coll Pharm, Dept Pharmaceut Sci, Little Rock, AR 72205 USA 3.Auburn Univ, Mat Res & Educ Ctr, Dept Mech Engn, Mat Engn, Auburn, AL 36849 USA 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Guangzhou 528400, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Univ Iowa, Coll Pharm, Dept Pharmaceut Sci & Expt Therapeut, Iowa City, IA 52242 USA 7.Auburn Univ, Harrison Coll Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA |
| 推荐引用方式 GB/T 7714 | Kang, Xuejia,Huang, Yongzhuo,Wang, Huiyuan,et al. Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy[J]. PHARMACEUTICS,2024,16(1):28. |
| APA | Kang, Xuejia.,Huang, Yongzhuo.,Wang, Huiyuan.,Jadhav, Sanika.,Yue, Zongliang.,...&Babu, R. Jayachandra.(2024).Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy.PHARMACEUTICS,16(1),28. |
| MLA | Kang, Xuejia,et al."Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy".PHARMACEUTICS 16.1(2024):28. |
入库方式： OAI收割
来源：上海药物研究所
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