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Visualization of nasal powder distribution using biomimetic human nasal cavity model

文献类型：期刊论文

作者Su, Jiawen4,5; Liu, Yan3; Sun, Hongyu2; Naeem, Abid5; Xu, Huipeng2; Qu, Yue3; Wang, Caifen2,3; Li, Zeru2,7; Lu, Jianhua1; Wang, Lulu8
刊名ACTA PHARMACEUTICA SINICA B
出版日期2024
卷号14期号:1页码:392-404
ISSN号2211-3835
关键词Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing
DOI10.1016/j.apsb.2023.06.007
通讯作者Wang, Zhigang(hmrywzg@sina.com) ; Yang, Rui(yangr@nifdc.org.cn) ; Wu, Li(wuli@simm.ac.cn)
英文摘要Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity. However, no reliable method is currently available to assess its impact on delivery performance. In this study, a biomimetic nasal model based on three-dimensional (3D) reconstruction and three-dimensional printing (3DP) technology was developed for visualizing the deposition of drug powders in the nasal cavity. The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females. The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test. The experimental device produced the most satisfactory results with five spray times. Furthermore, particle sizes and spray angles were found to significantly affect the experimental device's performance and alter terns were investigated in a goat nasal cavity model and three male goat noses, confirming the in vitro and
WOS关键词METAL-ORGANIC FRAMEWORKS ; INTRANASAL DELIVERY ; DRUG-DELIVERY ; LIPID NANOPARTICLES ; PLGA NANOPARTICLES ; BRAIN ; SPRAY ; ROTIGOTINE ; CARRIERS
资助项目Key Program for International Science and Technology Cooperation Projects of China[2020YFE0201700] ; Innovation Leading Talents Short-term Program of Jiangxi Province, China[1262000102] ; Shanghai Science and Technology Plan (China)[21DZ2260400]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号WOS:001153092700001
源URL[http://119.78.100.183/handle/2S10ELR8/308975]  
专题中国科学院上海药物研究所
通讯作者Wang, Zhigang; Yang, Rui; Wu, Li
作者单位1.Nantong Haimen Peoples Hosp, Nantong 226199, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China
3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
4.Yangtze Delta Drug Adv Res Inst, Nantong 264000, Peoples R China
5.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China
6.Yantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
7.Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China
8.Natl Inst Food & Drug Control, Beijing 100000, Peoples R China
推荐引用方式
GB/T 7714		 Su, Jiawen,Liu, Yan,Sun, Hongyu,et al. Visualization of nasal powder distribution using biomimetic human nasal cavity model[J]. ACTA PHARMACEUTICA SINICA B,2024,14(1):392-404.
APA Su, Jiawen.,Liu, Yan.,Sun, Hongyu.,Naeem, Abid.,Xu, Huipeng.,...&Wu, Li.(2024).Visualization of nasal powder distribution using biomimetic human nasal cavity model.ACTA PHARMACEUTICA SINICA B,14(1),392-404.
MLA Su, Jiawen,et al."Visualization of nasal powder distribution using biomimetic human nasal cavity model".ACTA PHARMACEUTICA SINICA B 14.1(2024):392-404.

入库方式： OAI收割

来源：上海药物研究所

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