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Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation

文献类型：期刊论文

作者Cheng, Chen6,7; Ren, Chao5,8; Li, Mu-zi4; Liu, Yi-hui4; Yao, Ren-qi6,8; Yu, Yang3; Yu, Xuan2,7; Wang, Jian-li3; Wang, Li-xue6,8; Leng, Yu-chun2,7
刊名ACTA PHARMACOLOGICA SINICA
出版日期2024-01-24
页码16
关键词Traditional Chinese medicine XueBiJing sepsis mortality pharmacokinetic compatibility polypharmacology
ISSN号1671-4083
DOI10.1038/s41401-023-01224-1
通讯作者Li, Chuan(chli@simm.ac.cn) ; Yao, Yong-ming(c_ff@sina.com)
英文摘要Sepsis, a life-threatening health issue, lacks effective medicine targeting the septic response. In China, treatment combining the intravenous herbal medicine XueBiJing with conventional procedures reduces the 28-day mortality of critically ill patients by modulating septic response. In this study, we identified the combined active constituents that are responsible for the XueBiJing's anti-sepsis action. Sepsis was induced in rats by cecal ligation and puncture (CLP). The compounds were identified based on their systemic exposure levels and anti-sepsis activities in CLP rats that were given an intravenous bolus dose of XueBiJing. Furthermore, the identified compounds in combination were assessed, by comparing with XueBiJing, for levels of primary therapeutic outcome, pharmacokinetic equivalence, and pharmacokinetic compatibility. We showed that a total of 12 XueBiJing compounds, unchanged or metabolized, circulated with significant systemic exposure in CLP rats that received XueBiJing. Among these compounds, hydroxysafflor yellow A, paeoniflorin, oxypaeoniflorin, albiflorin, senkyunolide I, and tanshinol displayed significant anti-sepsis activities, which involved regulating immune responses, inhibiting excessive inflammation, modulating hemostasis, and improving organ function. A combination of the six compounds, with the same respective doses as in XueBiJing, displayed percentage survival and systemic exposure in CLP rats similar to those by XueBiJing. Both the combination and XueBiJing showed high degrees of pharmacokinetic compatibility regarding interactions among the six active compounds and influences of other circulating XueBiJing compounds. The identification of XueBiJing's pharmacologically significant constituents supports the medicine's anti-sepsis use and provides insights into a polypharmacology-based approach to develop medicines for effective sepsis management.
WOS关键词INJECTION ; PHARMACOKINETICS ; DISPOSITION ; TANSHINOL ; IDENTIFICATION ; CONSENSUS
资助项目National Natural Science Foundation of China[82192912] ; National Natural Science Foundation of China[82074176] ; National Natural Science Foundation of China[81801935] ; National Natural Science Foundation of China[82272187] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202009] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050306]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001147845900001
出版者NATURE PUBL GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/308981]  
专题新药研究国家重点实验室
通讯作者Li, Chuan; Yao, Yong-ming
作者单位1.Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Shanghai 100049, Peoples R China
3.Tianjin Chasesun Pharmaceut Co Ltd, Tianjin 301700, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
5.Capital Med Univ, Beijing Chaoyang Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Beijing 100853, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Translat Med Res Ctr, Med Innovat Res Div, Beijing 100853, Peoples R China
9.Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Chen,Ren, Chao,Li, Mu-zi,et al. Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation[J]. ACTA PHARMACOLOGICA SINICA,2024:16.
APA Cheng, Chen.,Ren, Chao.,Li, Mu-zi.,Liu, Yi-hui.,Yao, Ren-qi.,...&Yao, Yong-ming.(2024).Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation.ACTA PHARMACOLOGICA SINICA,16.
MLA Cheng, Chen,et al."Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation".ACTA PHARMACOLOGICA SINICA (2024):16.

入库方式： OAI收割

来源：上海药物研究所

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