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Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes

文献类型：期刊论文

作者Zhu, Jie7,8; Wang, Rui6,8; Yang, Chenxiao6,8; Shao, Xinyue7,8; Zhang, Yi5,8; Hou, Jiazhen8; Gao, Yanrong7,8; Ou, Ante7,8; Chen, Meiwan4; Huang, Yongzhuo1,2,3,7,8
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2024-02-01
卷号366页码:328-341
关键词Platelet Circulating tumor cells (CTCs) Glycolysis Metastasis Hybrid-membrane liposome Quercetin Shikonin
ISSN号0168-3659
DOI10.1016/j.jconrel.2023.12.052
通讯作者Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Activated platelets promote tumor progression and metastasis through active interactions with cancer cells, especially in promoting epithelial-mesenchymal transition (EMT) of tumor cells and shedding tumor cells into the blood. Blocking platelet -tumor cell interactions can be a potential strategy to inhibit tumor metastasis. Platelet activation requires energy produced from aerobic glycolysis. Based on this, we propose a platelet suppression strategy by reprogramming glucose metabolism of platelets, which has an advantage over conventional antiplatelet treatment that has a risk of serious hemorrhage. We develop a biomimetic delivery system using platelet membrane -hybridized liposomes (PM-Lipo) for codelivery of quercetin and shikonin to simultaneously inhibit lactate transporter MCT-4 and a glycolytic enzyme PKM2 for achieving metabolic reprogramming of platelets and suppressing platelet activation. Notably, PM-Lipo can also inhibit glycolysis in cancer cells, which actually takes "two -birds -one -stone" action. Consequently, the platelet -tumor cell interactions are inhibited. Moreover, PM-Lipo can bind with circulating tumor cells and reduce their seeding in the premetastatic microenvironment. The in vivo studies further demonstrated that PM-Lipo can effectively suppress primary tumor growth and reduce lung metastasis without affecting inherited functions of platelets. Reprogramming glycolysis of platelets can remodel the tumor immune microenvironment, including suppression of Treg and stimulation of CTLs.
WOS关键词BREAST-TUMOR ; TGF-BETA ; CELLS ; METABOLISM ; RELEASE
资助项目National Key Research and Development Program of China, China[2021YFC2400600] ; National Key Research and Development Program of China, China[2021YFE0103100] ; National Key Research and Development Program of China, China[2022YFE0203600] ; NFSC, China[81925035] ; Chinese Academy of Sciences President's International Fellowship Initiative[2024VBB0004] ; International Collaborative Projects for Grand Challenges of CAS[083GJHZ2023021GC] ; National Foreign Expert Program[82050410361] ; High-level Innovative Research Institute[2019B090904008] ; High-level Innovative Research Institute[2021B0909050003] ; Department of Science and Technology of Guangdong Province ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001154292400001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/309045]  
专题新药研究国家重点实验室
通讯作者Huang, Yongzhuo
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
2.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, Zhongshan 528437, Peoples R China
4.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
5.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Oral Dis, Shanghai Key Lab Stomatol, Dept Implant Dent,Coll Stomatol,Shanghai Jiao Tong, Shanghai, Peoples R China
6.Nanchang Univ, Coll Pharm, 461 Bayi Rd, Nanchang 330006, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Jie,Wang, Rui,Yang, Chenxiao,et al. Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes[J]. JOURNAL OF CONTROLLED RELEASE,2024,366:328-341.
APA Zhu, Jie.,Wang, Rui.,Yang, Chenxiao.,Shao, Xinyue.,Zhang, Yi.,...&Huang, Yongzhuo.(2024).Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes.JOURNAL OF CONTROLLED RELEASE,366,328-341.
MLA Zhu, Jie,et al."Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes".JOURNAL OF CONTROLLED RELEASE 366(2024):328-341.

入库方式： OAI收割

来源：上海药物研究所

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