Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation
文献类型：期刊论文
| 作者 | Cui, Xuewei8; He, Zhong7; Liang, Jianjia8; Wei, Mulan6; Guo, Zhiyong8; Zhou, Yiqing2,5; Qin, Ye3,4; Deng, Zhangshuang1,8 |
| 刊名 | JOURNAL OF DRUG TARGETING
 |
| 出版日期 | 2024-03-15 |
| 卷号 | 32期号:3页码:325-333 |
| ISSN号 | 1061-186X |
| 关键词 | Dehydrocurvularin nanoparticles breast cancer solubility tumour targeting |
| DOI | 10.1080/1061186X.2024.2309566 |
| 通讯作者 | Zhou, Yiqing(zhyq2012@gmail.com) ; Qin, Ye(ycqinye@163.com) ; Deng, Zhangshuang(dzs163@163.com) |
| 英文摘要 | Dehydrocurvularin (DCV) is a promising lead compound for anti-cancer therapy. Unfortunately, the development of DCV-based drugs has been hampered by its poor solubility and bioavailability. Herein, we prepared a DCV-loaded mPEG-PLGA nanoparticles (DCV-NPs) with improved drug properties and therapeutic efficacy. The spherical and discrete particles of DCV-NPs had a uniform diameter of 101.8 +/- 0.45 nm and negative zeta potential of -22.5 +/- 1.12 mV (pH = 7.4), and its entrapment efficiency (EE) and drug loading (DL) were similar to 53.28 +/- 1.12 and 10.23 +/- 0.30%, respectively. In vitro the release of DCV-NPs lasted for more than 120 h in a sustained-release pattern, its antiproliferation efficacy towards breast cancer cell lines (MCF-7, MDA-MB-231, and 4T1) was better than that of starting drug DCV, and it could be efficiently and rapidly internalised by breast cancer cells. In vivo DCV-NPs were gradually accumulated in tumour areas of mice and significantly suppressed tumour growth. In summary, loading water-insoluble DCV onto nanoparticles has the potential to be an effective agent for breast cancer therapy with injectable property and tumour targeting capacity. |
| 资助项目 | National Natural Science Foundation of China[32172194] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:001156506100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309048]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, Yiqing; Qin, Ye; Deng, Zhangshuang |
| 作者单位 | 1.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China 2.Changshu Inst Technol, Sch Biotechnol & Food Engn, Changshu 215500, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai, Peoples R China 5.Changshu Inst Technol, Sch Biotechnol & Food Engn, Changshu, Jiangsu, Peoples R China 6.Yiling Hosp Yichang, Dept Pathol, Yichang, Peoples R China 7.China Three Gorges Univ, Coll Basic Med Sci, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang, Hubei, Peoples R China 8.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Xuewei,He, Zhong,Liang, Jianjia,et al. Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation[J]. JOURNAL OF DRUG TARGETING,2024,32(3):325-333. |
| APA | Cui, Xuewei.,He, Zhong.,Liang, Jianjia.,Wei, Mulan.,Guo, Zhiyong.,...&Deng, Zhangshuang.(2024).Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation.JOURNAL OF DRUG TARGETING,32(3),325-333. |
| MLA | Cui, Xuewei,et al."Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation".JOURNAL OF DRUG TARGETING 32.3(2024):325-333. |
入库方式： OAI收割
来源：上海药物研究所
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