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Recent advances in antibody glycoengineering for the of functions

文献类型：期刊论文

作者Liu, Zhi1,2,3; Zou, Xiangman1; Tang, Feng1; Huang, Wei1,2,3
刊名CURRENT OPINION IN CHEMICAL BIOLOGY
出版日期2024-02-01
卷号78页码:10
ISSN号1367-5931
关键词Antibody glycoengineering Endoglycosidase Chemo-enzymatic Glycosyltransferase Antibody-drug conjugates
DOI10.1016/j.cbpa.2023.102420
通讯作者Tang, Feng(tangfeng2013@simm.ac.cn) ; Huang, Wei(huangwei@simm.ac.cn)
英文摘要Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemoenzymatic antibody glycoengineering, and yeast expression system -based antibody engineering, as well as the applications of glycoengineering in antibody -drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.
WOS关键词HOST-CELL LINE ; GLYCAN STRUCTURE ; CHEMOENZYMATIC SYNTHESIS ; GLYCOSYNTHASE MUTANTS ; N-ACETYLGLUCOSAMINE ; IGG ANTIBODIES ; GLYCOSYLATION ; SITE ; ENDOGLYCOSIDASE ; SIALYLATION
资助项目National Key Research and Development Plan grant of China[2021YEE0200500] ; Natural Science Foundation of China (NSFC)[82325045] ; Natural Science Foundation of China (NSFC)[92153301] ; Natural Science Foundation of China (NSFC)[82003574] ; Natural Science Foundation of China (NSFC)[82204183] ; Natural Science Foundation of China (NSFC)[22277126] ; Lingang Laboratory[LG-QS-202206-03] ; SANOFI Scholarship Program
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:001154195700001
源URL[http://119.78.100.183/handle/2S10ELR8/309054]  
专题中国科学院上海药物研究所
通讯作者Tang, Feng; Huang, Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Biotherapeut Discovery Res, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Lingang Lab, Shanghai 200031, Peoples R China
3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Zhi,Zou, Xiangman,Tang, Feng,et al. Recent advances in antibody glycoengineering for the of functions[J]. CURRENT OPINION IN CHEMICAL BIOLOGY,2024,78:10.
APA Liu, Zhi,Zou, Xiangman,Tang, Feng,&Huang, Wei.(2024).Recent advances in antibody glycoengineering for the of functions.CURRENT OPINION IN CHEMICAL BIOLOGY,78,10.
MLA Liu, Zhi,et al."Recent advances in antibody glycoengineering for the of functions".CURRENT OPINION IN CHEMICAL BIOLOGY 78(2024):10.

入库方式： OAI收割

来源：上海药物研究所

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