Koilodenoids A-G, immunosuppressive spiro dimers of diterpenoids from Koilodepas hainanense: structural elucidation and biomimetic transformation
文献类型：期刊论文
| 作者 | Ren, Yu3; Zheng, Cheng-Yu3; Yao, Jia-Ying2; He, Shi-Jun2; Fan, Yao-Yue3; Yue, Jian-Min1,3
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2024-01-30 |
| 页码 | 8 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d3qo01967e |
| 通讯作者 | He, Shi-Jun(heshijun@shutcm.edu.cn) ; Fan, Yao-Yue(s040500290@126.com) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Seven undescribed dimeric diterpenoids, koilodenoids 1-7, were isolated from Koilodepas hainanense. Compound 1 possesses a new carbon skeleton featuring a unique oxaspiro[5.9]pentadecane fragment. Compounds 2-7 share a 6/6/6/6/6/6/6-fused heptacyclic framework with a rare oxaspiro[5.5]undecane motif. Their structures were characterized by a combination of diverse methods. Biomimetic transformation of 2 into 1 was achieved in high yield by photochemical oxidation under mild, as well as peroxide- and metal-free conditions. Compounds 1-7 showed moderate immunosuppressive activity. |
| WOS关键词 | CLEAVAGE |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[82122062] ; National Natural Science Foundation[2019-I2M-5-080] ; CAMS Innovation Fund for Medical Sciences[KFJ-BRP-008] ; CAS Biological Resources Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001153891000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309082]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | He, Shi-Jun; Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Med Sci, Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Yu,Zheng, Cheng-Yu,Yao, Jia-Ying,et al. Koilodenoids A-G, immunosuppressive spiro dimers of diterpenoids from Koilodepas hainanense: structural elucidation and biomimetic transformation[J]. ORGANIC CHEMISTRY FRONTIERS,2024:8. |
| APA | Ren, Yu,Zheng, Cheng-Yu,Yao, Jia-Ying,He, Shi-Jun,Fan, Yao-Yue,&Yue, Jian-Min.(2024).Koilodenoids A-G, immunosuppressive spiro dimers of diterpenoids from Koilodepas hainanense: structural elucidation and biomimetic transformation.ORGANIC CHEMISTRY FRONTIERS,8. |
| MLA | Ren, Yu,et al."Koilodenoids A-G, immunosuppressive spiro dimers of diterpenoids from Koilodepas hainanense: structural elucidation and biomimetic transformation".ORGANIC CHEMISTRY FRONTIERS (2024):8. |
入库方式： OAI收割
来源：上海药物研究所
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