Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats
文献类型：期刊论文
| 作者 | Chen, Ruo-song2,3; Liu, Jing2,5; Wang, Yu-jun2 ; Ning, Kuan1,2; Liu, Jing-gen2,4; Liu, Zhi-qiang3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2024-02-07 |
| 页码 | 14 |
| ISSN号 | 1671-4083 |
| 关键词 | heroin addiction drug taking and seeking context-induced relapse ventral pallidum lateral habenula glutamatergic neurons |
| DOI | 10.1038/s41401-024-01229-4 |
| 通讯作者 | Liu, Jing-gen(jgliu@simm.ac.cn) ; Liu, Zhi-qiang(drliuzhiqiang@163.com) |
| 英文摘要 | Glutamatergic neurons in ventral pallidum (VPGlu) were recently reported to mediate motivational and emotional behavior, but its role in opioid addiction still remains to be elucidated. In this study we investigated the function of VPGlu in the context-dependent heroin taking and seeking behavior in male rats under the ABA renewal paradigm. By use of cell-type-specific fiber photometry, we showed that the calcium activity of VPGlu were inhibited during heroin self-administration and context-induced relapse, but activated after extinction in a new context. The drug seeking behavior was accompanied by the decreased calcium signal of VPGlu. Chemogenetic manipulation of VPGlu bidirectionally regulated heroin taking and seeking behavior. Anterograde tracing showed that the lateral habenula, one of the epithalamic structures, was the major output region of VPGlu, and its neuronal activity was consistent with VPGlu in different phases of heroin addiction and contributed to the motivation for heroin. VPGlu axon terminals in LHb exhibited dynamic activity in different phases of heroin addiction. Activation of VPGlu-LHb circuit reduced heroin seeking behavior during context-induced relapse. Furthermore, the balance of excitation/inhibition from VP to LHb was shifted to enhanced glutamate transmission after extinction of heroin seeking motivation. Overall, the present study demonstrated that the activity of VPGlu was involved in the regulation of heroin addiction and identified the VPGlu-LHb pathway as a potential intervention to reduce heroin seeking motivation. |
| WOS关键词 | LATERAL HABENULA ; INDUCED RELAPSE ; GABA NEURONS ; DRUG SEEKING ; COCAINE ; REWARD ; REINSTATEMENT ; CIRCUITRY |
| 资助项目 | Major Project of the Science and Technology Innovation 2030 of China[2021ZD0203500] ; Major Project of the Science and Technology Innovation 2030 of China[2021ZD0202900] ; National Natural Science Foundation of China[82030112] ; National Natural Science Foundation of China[81773710] ; National Natural Science Foundation of China[82371533] ; National Natural Science Foundation of China[82301677] ; Science and Technology Commission of Shanghai Municipality[20ZR1468200] ; Natural Science Foundation of Shanghai[22ZR1449300] ; Program of Shanghai Academic/Technology Research Leader[22XD1402400] ; Program of Shanghai Academic/Technology Research Leader[NYKFKT2019015] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | NATURE PUBL GROUP |
| WOS记录号 | WOS:001157144500002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309088]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Jing-gen; Liu, Zhi-qiang |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Neurol & Psychiat Res & Drug Discovery, Shanghai 201203, Peoples R China 3.Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai Inst Maternal Fetal Med & Gynecol Oncol, Sch Med,Shanghai Key Lab Maternal Fetal Med,Dept A, Shanghai 201204, Peoples R China 4.Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pro, Hangzhou 310053, Peoples R China 5.China Pharmaceut Univ, Sch Biopharm, State Key Lab Nat Med, Nanjing 211198, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Ruo-song,Liu, Jing,Wang, Yu-jun,et al. Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats[J]. ACTA PHARMACOLOGICA SINICA,2024:14. |
| APA | Chen, Ruo-song,Liu, Jing,Wang, Yu-jun,Ning, Kuan,Liu, Jing-gen,&Liu, Zhi-qiang.(2024).Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats.ACTA PHARMACOLOGICA SINICA,14. |
| MLA | Chen, Ruo-song,et al."Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats".ACTA PHARMACOLOGICA SINICA (2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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