Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica
文献类型：期刊论文
| 作者 | Li, Jia-yuan1; Wu, Shi-fei1; An, Ya-ling1,2; Yao, Chang-liang1; Yao, Shuai1; Wei, Wen-long1; Zhang, Jian-qing1; Bi, Qi-rui1; Guo, Dean1,2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2024-01-31 |
| 卷号 | 87期号:2页码:252-265 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00910 |
| 通讯作者 | Guo, Dean(daguo@simm.ac.cn) |
| 英文摘要 | Eleven new steroidal alkaloids, along with nine known related compounds, were isolated from the bulbs of Fritillaria sinica. Seven pairs of diastereomers were identified, including six and four 20-deoxy cevanine-type steroidal alkaloid diastereomers with molecular weights of 413 and 415, respectively. Structures were elucidated based on spectroscopic data analysis, chemical derivatization, and single-crystal X-ray diffraction analysis. Compounds 5, 9, 11, 12, 16, and 20 exhibited significant in vitro cytotoxic activity against non-small-cell lung cancer with CC50 values from 6.8 +/- 3.9 to 12 +/- 5 mu M. |
| WOS关键词 | ISOSTEROIDAL ALKALOIDS |
| 资助项目 | Key Program of National Natural Science Foundation of China ; Qi-Huang Chief Scientist Project of National Administration of Traditional Chinese Medicine[82130111] ; Key Program of National Natural Science Foundation of China |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001159018300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309198]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Dean |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jia-yuan,Wu, Shi-fei,An, Ya-ling,et al. Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica[J]. JOURNAL OF NATURAL PRODUCTS,2024,87(2):252-265. |
| APA | Li, Jia-yuan.,Wu, Shi-fei.,An, Ya-ling.,Yao, Chang-liang.,Yao, Shuai.,...&Guo, Dean.(2024).Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica.JOURNAL OF NATURAL PRODUCTS,87(2),252-265. |
| MLA | Li, Jia-yuan,et al."Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica".JOURNAL OF NATURAL PRODUCTS 87.2(2024):252-265. |
入库方式： OAI收割
来源：上海药物研究所
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