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Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery

文献类型：期刊论文

作者Miao, Yunqiu1,5; Li, Lijun4,5; Wang, Ying4,5; Wang, Jiangyue5; Zhou, Yihan5; Guo, Linmiao5; Zhao, Yanqi4,5; Nie, Di5; Zhang, Yang1; Zhang, Xinxin3,4,5
刊名NATURE COMMUNICATIONS
出版日期2024-02-07
卷号15期号:1页码:20
DOI10.1038/s41467-024-45254-7
通讯作者Zhang, Xinxin(xinxinzhang@simm.ac.cn) ; Gan, Yong(ygan@simm.ac.cn)
英文摘要The dynamic protein corona formed on nanocarriers has been revealed to strongly affect their in vivo behaviors. Precisely manipulating the formation of protein corona on nanocarriers may provide an alternative impetus for specific drug delivery. Herein, we explore the role of glycosylated polyhydroxy polymer-modified nanovesicles (CP-LVs) with different amino/hydroxyl ratios in protein corona formation and evolution. CP-LVs with an amino/hydroxyl ratio of approximately 0.4 (CP1-LVs) are found to efficiently suppress immunoglobulin adsorption in blood and livers, resulting in prolonged circulation. Moreover, CP1-LVs adsorb abundant tumor distinctive proteins, such as CD44 and osteopontin in tumor interstitial fluids, mediating selective tumor cell internalization. The proteins corona transformation specific to the environment appears to be affected by the electrostatic interaction between CP-LVs and proteins with diverse isoelectric points. Benefiting from surface modification-mediated protein corona regulation, paclitaxel-loaded CP1-LVs demonstrate superior antitumor efficacy to PEGylated liposomes. Our work offers a perspective on rational surface-design of nanocarriers to modulate the protein corona formation for efficient drug delivery. The dynamic protein corona hinders the uptake of nanocarriers in desired target cell populations, limiting their bench-to-bedside translation. Here the authors reveal that the modification of hydroxyl and amino functional groups on nanovesicles can rationally regulate the composition of protein coronas to improve the efficiency of targeted drug delivery.
WOS关键词NANOPARTICLES ; SURFACE
资助项目National Natural Science Foundation of China (National Science Foundation of China)[82025032] ; National Science Fund for Distinguished Young Scholars[82104113] ; National Science Fund for Distinguished Young Scholars[82222066] ; National Science Fund for Distinguished Young Scholars[81973250] ; National Natural Science Foundation of China[2022T150675] ; China Postdoctoral Science Foundation[21ZR1475800] ; Natural Science Foundation of Shanghai[SIMM2103ZZ-01] ; State Key Laboratory of Drug Research ; Shanghai Advanced Research Institute, Chinese Academy of Sciences, China
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PORTFOLIO
WOS记录号WOS:001159313700035
源URL[http://119.78.100.183/handle/2S10ELR8/309201]  
专题中国科学院上海药物研究所
通讯作者Zhang, Xinxin; Gan, Yong
作者单位1.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Shanghai 200072, Peoples R China
2.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Miao, Yunqiu,Li, Lijun,Wang, Ying,et al. Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery[J]. NATURE COMMUNICATIONS,2024,15(1):20.
APA Miao, Yunqiu.,Li, Lijun.,Wang, Ying.,Wang, Jiangyue.,Zhou, Yihan.,...&Gan, Yong.(2024).Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery.NATURE COMMUNICATIONS,15(1),20.
MLA Miao, Yunqiu,et al."Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery".NATURE COMMUNICATIONS 15.1(2024):20.

入库方式： OAI收割

来源：上海药物研究所

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