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Synthesis of 1,4-epoxy-2-aryltetrahydro-1-benzazepines via rhodium(iii)-catalyzed C-H allylation/intramolecular 1,3-dipolar cycloaddition

文献类型：期刊论文

作者Wang, Xuan3,4; Li, Jianlong2,4; Du, Haifang1,4; Liang, Weihong2,4; Luo, Cheng3; Wu, Yunshan2,4; Liu, Bo2,4,5
刊名CHEMICAL COMMUNICATIONS
出版日期2024-02-22
卷号60期号:17页码:2401-2404
ISSN号1359-7345
DOI10.1039/d3cc05082c
通讯作者Wu, Yunshan(wysh2005@hotmail.com) ; Liu, Bo(doctliu@263.net)
英文摘要Herein, we report a new synthetic route to 1,4-epoxy-2-aryltetrahydro-1-benzazepine derivatives with high efficiency, namely the Rh(iii)-catalyzed C-H allylation of nitrones with allyl precursors, followed by subsequent intramolecular 1,3-dipolar cycloaddition, to deliver the title compounds. This reaction is regio- and stereo-selective, generating the cis-isomer with a broad substrate scope and good functional group tolerance.
WOS关键词DIAZO-COMPOUNDS ACCESS ; STEREOSELECTIVE-SYNTHESIS ; ANTIPARASITIC ACTIVITY ; TRYPANOSOMA-CRUZI ; ACTIVATION ; ARYLNITRONES ; CYCLIZATION ; NITRONES ; ARENES ; ALLYL
资助项目National Natural Science Foundation of China[82304703] ; China Postdoctoral Science Foundation[2022M720859] ; Basic and Applied Basic Research Foundation of Guangdong Province[2022A1515111127] ; Basic and Applied Basic Research Foundation of Guangdong Province[2023B1212060063] ; Basic and Applied Basic Research Foundation of Guangdong Province[2022A1515010103] ; Guangzhou Municipal Science and Technology Project[2023A04J0468] ; Guangzhou Municipal Science and Technology Project[2023A04J0478] ; Guangzhou Municipal Science and Technology Project[2023A04J0479] ; Guangzhou Municipal Science and Technology Project[202201020488] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2019MJ05] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2020QN02] ; Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine[BJ2022KY08] ; Collaborative innovation project of Guangzhou University of Chinese Medicine[2021xk69] ; Collaborative innovation project of Guangzhou University of Chinese Medicine[2021xk08] ; Special Funds for State Key Laboratory of Dampness Syndrome of Chinese Medicine[SZ2021ZZ33] ; Special Funds for State Key Laboratory of Dampness Syndrome of Chinese Medicine[SZ2023ZZ13]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:001158890200001
源URL[http://119.78.100.183/handle/2S10ELR8/309219]  
专题中国科学院上海药物研究所
通讯作者Wu, Yunshan; Liu, Bo
作者单位1.Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou 510006, Peoples R China
2.Guangzhou Key Lab Chiral Res Act Components Tradit, Guangzhou 510006, Peoples R China
3.Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Chinese Acad Sci, Zhongshan 528400, Peoples R China
4.Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Guangzhou 510006, Peoples R China
5.State Key Lab Dampness Syndrome Chinese Med, Guangzhou 510006, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xuan,Li, Jianlong,Du, Haifang,et al. Synthesis of 1,4-epoxy-2-aryltetrahydro-1-benzazepines via rhodium(iii)-catalyzed C-H allylation/intramolecular 1,3-dipolar cycloaddition[J]. CHEMICAL COMMUNICATIONS,2024,60(17):2401-2404.
APA Wang, Xuan.,Li, Jianlong.,Du, Haifang.,Liang, Weihong.,Luo, Cheng.,...&Liu, Bo.(2024).Synthesis of 1,4-epoxy-2-aryltetrahydro-1-benzazepines via rhodium(iii)-catalyzed C-H allylation/intramolecular 1,3-dipolar cycloaddition.CHEMICAL COMMUNICATIONS,60(17),2401-2404.
MLA Wang, Xuan,et al."Synthesis of 1,4-epoxy-2-aryltetrahydro-1-benzazepines via rhodium(iii)-catalyzed C-H allylation/intramolecular 1,3-dipolar cycloaddition".CHEMICAL COMMUNICATIONS 60.17(2024):2401-2404.

入库方式： OAI收割

来源：上海药物研究所

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