Molecular Engineering of Bright NIR-I/NIR-II Nanofluorophores for High-Resolution Bioimaging and Tumor Detection in Vivo
文献类型：期刊论文
| 作者 | Zhou, Xiaobo3; Fan, Yiwei1,2; Li, Shijie3; Zhang, Ke3; Pei, Yuetian1,2; Zeng, Yuhan3; Kang, Xiaoxia3; Zhao, Lingfeng3; Chen, Hao4; Qin, Yuling3 |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2024-01-26 |
| 卷号 | 24期号:5页码:1792-1800 |
| ISSN号 | 1530-6984 |
| 关键词 | NIR-I/NIR-II fluorophore organic nanodots fluorescence imaging tumor detection |
| DOI | 10.1021/acs.nanolett.3c04976 |
| 通讯作者 | Feng, Wei(fengweifd@fudan.edu.cn) ; Liu, Lingxiao(liulingxiao2022@163.com) ; Wu, Li(wuli8686@ntu.edu.cn) |
| 英文摘要 | A comprehensive approach for the construction of NIR-I/NIR-II nanofluorophores with exceptional brightness and excellent chemo- and photostability has been developed. This study first confirmed that the amphiphilic molecules with stronger hydrophobic moieties and weaker hydrophilic moieties are superior candidates for constructing brighter nanofluorophores, which are attributed to its higher efficiency in suppressing the intramolecular charge transfer/aggregation-caused fluorescence quenching of donor-acceptor-donor type fluorophores. The prepared nanofluorophore demonstrates a fluorescence quantum yield exceeding 4.5% in aqueous solution and exhibits a strong NIR-II tail emission up to 1300 nm. The superior performance of the nanofluorophore enabled the achievement of high-resolution whole-body vessel imaging and brain vessel imaging, as well as high-contrast fluorescence imaging of the lymphatic system in vivo. Furthermore, their potential for highly sensitive fluorescence detection of tiny tumors in vivo has been successfully confirmed, thus supporting their future applications in precise fluorescence imaging-guided surgery in the early stages of cancer. |
| WOS关键词 | RATIONAL DESIGN ; FLUOROPHORES ; NANOPARTICLES ; WAVELENGTHS ; SURGERY ; DYES |
| 资助项目 | National Natural Science Foundation of China[62005132] ; National Natural Science Foundation of China[82373456] ; National Natural Science Foundation of China[32171452] ; National Natural Science Foundation of China[06200048] ; National Natural Science Foundation of China[06200053] ; National Natural Science Foundation of China[BK20220060] ; Excellent Youth Foundation of Jiangsu Scientific Committee ; Large Instruments Open Foundation of Nantong University |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001158687300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309231]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, Wei; Liu, Lingxiao; Wu, Li |
| 作者单位 | 1.Fudan Univ, Polymers & Acad Engn & Technol, State Key Lab Mol Engn, Shanghai 200433, Peoples R China 2.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China 3.Nantong Univ, Sch Publ Hlth, Nantong Key Lab Publ Hlth & Med Anal, Nantong 226019, Jiangsu, Peoples R China 4.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Dept Intervent Radiol, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xiaobo,Fan, Yiwei,Li, Shijie,et al. Molecular Engineering of Bright NIR-I/NIR-II Nanofluorophores for High-Resolution Bioimaging and Tumor Detection in Vivo[J]. NANO LETTERS,2024,24(5):1792-1800. |
| APA | Zhou, Xiaobo.,Fan, Yiwei.,Li, Shijie.,Zhang, Ke.,Pei, Yuetian.,...&Wu, Li.(2024).Molecular Engineering of Bright NIR-I/NIR-II Nanofluorophores for High-Resolution Bioimaging and Tumor Detection in Vivo.NANO LETTERS,24(5),1792-1800. |
| MLA | Zhou, Xiaobo,et al."Molecular Engineering of Bright NIR-I/NIR-II Nanofluorophores for High-Resolution Bioimaging and Tumor Detection in Vivo".NANO LETTERS 24.5(2024):1792-1800. |
入库方式： OAI收割
来源：上海药物研究所
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