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A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for I n Vivo I maging of Amyloid-β Species

文献类型：期刊论文

作者Fang, Daqing1,2; Pan, Donghui3; Wen, Xidan1; Zhang, Junya1; Yang, Min3; Ye, Deju1; Liu, Hong2
刊名ACS CHEMICAL NEUROSCIENCE
出版日期2024-01-12
卷号15期号:3页码:472-478
ISSN号1948-7193
关键词A beta species Alzheimer's disease NIR fluorescence imaging PET imaging bimodalprobe APP/PS1
DOI10.1021/acschemneuro.3c00377
通讯作者Ye, Deju(dejuye@nju.edu.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要Noninvasive imaging of amyloid-beta (A beta) species in vivo is important for the early diagnosis of Alzheimer's disease (AD). In this paper, we report a near-infrared (NIR) fluorescence (FL) and positron emission tomography (PET) bimodal probe (NIR-[Ga-68]) for in vivo imaging of both soluble and insoluble A beta species. NIR-[Ga-68] holds a high binding affinity, high selectivity and high sensitivity toward A beta 42 monomers, oligomers, and aggregates in vitro. In vivo imaging results show that NIR-[Ga-68] can cross the blood-brain-barrier (BBB), and produce significantly higher PET and NIR FL bimodal signals in the brains of APP/PS1 transgenic AD mice relative to that of age-matched wild-type mice, which are also validated by the ex vivo autoradiography and histological staining images. Our results demonstrate that NIR-[Ga-68] is an efficient NIR FL and PET bimodal probe for the sensitive imaging of soluble and insoluble A beta species in AD mice.
WOS关键词IMAGING PROBES ; ALZHEIMERS-DISEASE ; METAL-COMPLEXES ; RECENT PROGRESS ; OLIGOMERS ; MECHANISMS ; DEPOSITS ; PLAQUES
资助项目National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[22274074] ; National Natural Science Foundation of China[22137003] ; National Natural Science Foundation of China[020514380251] ; National Natural Science Foundation of China[020514380310] ; Fundamental Research Funds for the Central Universities[ZYJH004] ; Excellent Research Program of Nanjing University
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001158696900001
源URL[http://119.78.100.183/handle/2S10ELR8/309234]  
专题中国科学院上海药物研究所
通讯作者Ye, Deju; Liu, Hong
作者单位1.Nanjing Univ, Chem & Biomed Innovat Ctr ChemB, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Jiangsu Inst Nucl Med, NHC Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Wuxi 214063, Peoples R China
推荐引用方式
GB/T 7714		 Fang, Daqing,Pan, Donghui,Wen, Xidan,et al. A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for I n Vivo I maging of Amyloid-β Species[J]. ACS CHEMICAL NEUROSCIENCE,2024,15(3):472-478.
APA Fang, Daqing.,Pan, Donghui.,Wen, Xidan.,Zhang, Junya.,Yang, Min.,...&Liu, Hong.(2024).A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for I n Vivo I maging of Amyloid-β Species.ACS CHEMICAL NEUROSCIENCE,15(3),472-478.
MLA Fang, Daqing,et al."A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for I n Vivo I maging of Amyloid-β Species".ACS CHEMICAL NEUROSCIENCE 15.3(2024):472-478.

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来源：上海药物研究所

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