中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
A NIR-II Photoacoustic/NIR-IIa Fluorescent Probe for Targeted Imaging of Glioma under NIR-II Excitation

文献类型：期刊论文

作者Lyu, Shuxin2,3; Lu, Siyu3,4,5,6; Gui, Conghao1,3,7; Guo, Chunyan2; Han, Juanjuan2; Xiao, Yuling3,4,5,6; Zhang, Ruiping2; Hong, Xuechuan1,3,7
刊名JOURNAL OF MEDICINAL CHEMISTRY
出版日期2024-01-22
卷号67期号:3页码:1861-1871
ISSN号0022-2623
DOI10.1021/acs.jmedchem.3c01515
通讯作者Xiao, Yuling(xiaoyl@whu.edu.cn) ; Zhang, Ruiping(zrp_7142@sxmu.edu.cn) ; Hong, Xuechuan(xhy78@whu.edu.cn)
英文摘要Fluorescence and photoacoustic (PA) imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has garnered massive interest owing to high maximum permissible exposure of light, reduced autofluorescence, and improved deep penetration. However, active targeted NIR-II photoacoustic/NIR-IIa fluorescence imaging of glioma under NIR-II excitation has been seldom reported, which is partly ascribable to the lack of suitable materials. In this study, a small-molecule-based alpha(v)beta(3)-targeted NIR-II photoacoustic/NIR-IIa fluorescent probe IR-32p was generated and subsequently evaluated in U87MG tumor-bearing mice excited with NIR-I and NIR-II light. Exceptional dual-modal imaging properties such as good tumor uptake, high targeting specificity, and high tumor contrast were achieved in an orthotopic glioma model under 1020/1064 nm excitation, exhibiting a superior imaging depth of glioma through the skull. Our study introduces an outstanding dual-modal contrast agent with NIR-II absorption and confirms the superiority of NIR-II excitation over NIR-I in in vivo NIR-II/PA imaging.
WOS关键词CARBON NANOTUBES ; MICELLES ; DELIVERY ; AGENTS ; NANOPARTICLES ; FLUOROPHORES ; ABSORPTION
资助项目Health Commission of Shanxi Province[2023YFC3605502] ; Health Commission of Shanxi Province[2020YFA0908800] ; National Key Research and Development Program of China[82273796] ; National Key Research and Development Program of China[82120108016] ; National Key Research and Development Program of China[82071987] ; National Natural Science Foundation of China[ZR2023MB085] ; Natural Science Foundation of Shandong Province[SYS202205] ; Shandong Laboratory Program[JCYJ20220530140605012] ; Shandong Laboratory Program[JCYJ20230807090100002] ; Shenzhen Science and Technology Research Grant[2023A1515012649] ; Guangdong Basic and Applied Basic Research Foundation[XZ202301ZY0014G] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[SQ2022RA2A300118] ; National Ten Thousand Talent Program[2020-177] ; Shanxi Scholarship Council of China[2020TD11] ; Shanxi Scholarship Council of China[2020SYS15] ; Shanxi Scholarship Council of China[2020XM10] ; Four Batches of Scientific Research Projects of Shanxi Provincial Health Commission[202104010910010] ; Key Laboratory of Nanoimaging
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001159166900001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/309246]  
专题新药研究国家重点实验室
通讯作者Xiao, Yuling; Zhang, Ruiping; Hong, Xuechuan
作者单位1.Wuhan Univ, Shenzhen Res Inst, Key Lab Virol & Biosafety CAS, Shenzhen 518057, Peoples R China
2.Shanxi Med Univ, Shanxi Acad Med Sci, Shanxi Bethune Hosp, Hosp 3, Taiyuan 030032, Peoples R China
3.Wuhan Univ, Zhongnan Hosp, Clin Trial Ctr, Sch Pharmaceut Sci,Dept Cardiol, Wuhan 430071, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
7.Tibet Univ, Coll Sci, Res Ctr Ecol, Lab Extreme Environm Biol Resources & Adapt Evolut, Lhasa 850000, Peoples R China
推荐引用方式
GB/T 7714		 Lyu, Shuxin,Lu, Siyu,Gui, Conghao,et al. A NIR-II Photoacoustic/NIR-IIa Fluorescent Probe for Targeted Imaging of Glioma under NIR-II Excitation[J]. JOURNAL OF MEDICINAL CHEMISTRY,2024,67(3):1861-1871.
APA Lyu, Shuxin.,Lu, Siyu.,Gui, Conghao.,Guo, Chunyan.,Han, Juanjuan.,...&Hong, Xuechuan.(2024).A NIR-II Photoacoustic/NIR-IIa Fluorescent Probe for Targeted Imaging of Glioma under NIR-II Excitation.JOURNAL OF MEDICINAL CHEMISTRY,67(3),1861-1871.
MLA Lyu, Shuxin,et al."A NIR-II Photoacoustic/NIR-IIa Fluorescent Probe for Targeted Imaging of Glioma under NIR-II Excitation".JOURNAL OF MEDICINAL CHEMISTRY 67.3(2024):1861-1871.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。