Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine
文献类型：期刊论文
| 作者 | Zhao, Pengfei1,4; Tang, Xueping1,5; Huang, Yongzhuo1,2,3
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| 刊名 | View
 |
| 出版日期 | 2021-02-10 |
| 卷号 | 2期号:4页码:20200127 |
| 关键词 | combination therapy disulfiram drug repositioning nanotechnology tumor-targetingdelivery |
| ISSN号 | 2688-268X |
| DOI | 10.1002/VIW.20200127 |
| 英文摘要 | The increasing incidence and mortality of malignant tumors have required the development of diversified innovative therapies. Compared with the new therapeutic molecule invention, it is a more economical and efficient way to reposition old drugs that have been marketed or in clinical trials for tumor treatment. Studies have been carried out for repositioning the old approval drugs that are widely applied clinically with reliable biosafety and effectiveness evidence, including aspirin, artemisinin (and its derivatives, eg, dihydroartemisinin), metformin, and disulfiram (DSF). In addition to the approved pharmacological activity, these old drugs exhibited broad tumor-suppressive effects. This review summarizes the drug repositioning strategy of DSF through nanotechnology and outlines the DSF nano-formulations for cancer targeting delivery and therapy. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309250]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 2.NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Shanghai, China; 3.Zhongshan Institute for Drug Discovery, Institutes of Drug Discovery and Development, Chinese Academy of Sciences, Zhongshan, China 4.School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China; 5.Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China; |
| 推荐引用方式 GB/T 7714 | Zhao, Pengfei,Tang, Xueping,Huang, Yongzhuo. Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine[J]. View,2021,2(4):20200127. |
| APA | Zhao, Pengfei,Tang, Xueping,&Huang, Yongzhuo.(2021).Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine.View,2(4),20200127. |
| MLA | Zhao, Pengfei,et al."Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine".View 2.4(2021):20200127. |
入库方式： OAI收割
来源：上海药物研究所
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