Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
文献类型：期刊论文
| 作者 | Liu, Chang1,3; Jiang, Xiaohe1,3; Gan, Yong1,2,3 ; Yu, Miaorong1
|
| 刊名 | Medicine in Drug Discovery
 |
| 出版日期 | 2021-12-03 |
| 卷号 | 12页码:100110 |
| 关键词 | Mucus barrier Mucosal drug delivery Nanoparticles Particle tracking experiments Mucus-penetrating nanoparticles |
| ISSN号 | 2590-0986 |
| DOI | 10.1016/j.medidd.2021.100110 |
| 英文摘要 | Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems (DDSs) can be easily trapped in the mucus network by steric obstruction and/or binding interactions and then are efficiently cleared away with rapid mucus turnover, thereby limiting mucosal drug delivery efficacy. Modulating the physicochemical properties of nanoparticles (NPs), including size, surface hydrophilicity and charge, shape, and rigidity, is an effective method to overcome the mucus barrier. This review first describes the protective barrier properties of mucus and how mucus affects the fate of NPs. It then reviews the techniques for evaluating particle movement in mucus, including macroscopic diffusivity and microcosmic diffusion mechanisms. The state-of-the-art strategies exploited by researchers to overcome the mucus barrier by using NPs are discussed. Finally, the dilemma and solutions of balancing both mucus penetration and cellular uptake barriers are discussed. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309251]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Miaorong |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2.NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China 3.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; |
| 推荐引用方式 GB/T 7714 | Liu, Chang,Jiang, Xiaohe,Gan, Yong,et al. Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art[J]. Medicine in Drug Discovery,2021,12:100110. |
| APA | Liu, Chang,Jiang, Xiaohe,Gan, Yong,&Yu, Miaorong.(2021).Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art.Medicine in Drug Discovery,12,100110. |
| MLA | Liu, Chang,et al."Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art".Medicine in Drug Discovery 12(2021):100110. |
入库方式： OAI收割
来源：上海药物研究所
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