Role of microRNAs in the process of metformin treating multiple diseases
文献类型：期刊论文
| 作者 | Ma, Ningning1,2,3; Chen, Jing2,3 ; Ren, Jin1,2,3
|
| 刊名 | Frigid Zone Medicine
 |
| 出版日期 | 2021-12-01 |
| 卷号 | 1期号:2页码:69-78 |
| 关键词 | metformin microRNA tumor metabolic diseases |
| ISSN号 | 2719-8073 |
| DOI | 10.2478/fzm-2021-0009 |
| 英文摘要 | Metformin as the first-line treatment for type 2 diabetes mellitus has been discovered to exert beneficial effects on many diseases for nearly ten years, but its specific mechanism is still unclear. As a new class of gene expression regulators with pleiotropic properties, microRNAs (miRNAs) participate in multiple physiological processes such as cell differentiation, proliferation, survival, and metabolism, which drive them to play a regulatory role in the occurrence, development and even treatment of various diseases. A substantial body of research has found the relationship between metformin and miRNAs, in which metformin can alter the expression profiles of miRNAs in multiple disease states and on the other hand the signal pathways involving miRNAs may contribute to the pharmacological actions of metformin. This review summarizes the effects of metformin on miRNAs and their relationship in different diseases (like tumor, metabolic diseases, etc.), which should be of a great help for our better understanding of the mechanism of metformin for treating multiple diseases. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309253]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Jing; Ren, Jin |
| 作者单位 | 1.School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Ma, Ningning,Chen, Jing,Ren, Jin. Role of microRNAs in the process of metformin treating multiple diseases[J]. Frigid Zone Medicine,2021,1(2):69-78. |
| APA | Ma, Ningning,Chen, Jing,&Ren, Jin.(2021).Role of microRNAs in the process of metformin treating multiple diseases.Frigid Zone Medicine,1(2),69-78. |
| MLA | Ma, Ningning,et al."Role of microRNAs in the process of metformin treating multiple diseases".Frigid Zone Medicine 1.2(2021):69-78. |
入库方式： OAI收割
来源：上海药物研究所
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