Nano drug delivery systems improve metastatic breast cancer therapy
文献类型：期刊论文
| 作者 | Zhu, Runqi1,2; Lang, Tianqun1,2,3; Yin, Qi1,2,3 ; Li, Yaping1,2,4,5
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| 刊名 | Medical review (Berlin, Germany)
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| 出版日期 | 2021-12-01 |
| 卷号 | 1期号:2页码:244-274 |
| ISSN号 | 2749-9642 |
| 关键词 | breast cancer drug delivery metastasis nanotechnology stimuli-responsive |
| DOI | 10.1515/mr-2021-0011 |
| 文献子类 | Article |
| 英文摘要 | Despite continual progress in the technologies and regimens for cancer therapy, the treatment outcome of fatal metastatic breast cancer is far from satisfactory. Encouragingly, nanotechnology has emerged as a valuable tool to optimize drug delivery process in cancer therapy via preventing the cargos from degradation, improving the tumor-targeting efficiency, enhancing therapeutic agents' retention in specific sites, and controlling drug release. In the last decade, several mechanisms of suppressing tumor metastasis by functional nano drug delivery systems (NDDSs) have been revealed and a guidance for the rational design of anti-metastasis NDDSs is summarized, which consist of three aspects: optimization of physiochemical properties, tumor microenvironment remodeling, and biomimetic strategies. A series of medicinal functional biomaterials and anti-metastatic breast cancer NDDSs constructed by our team are introduced in this review. It is hoped that better anti-metastasis strategies can be inspired and applied in clinic. |
| 语种 | 英语 |
| WOS记录号 | MEDLINE:37724299 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309291]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; 2.University of Chinese Academy of Sciences, Beijing, China.; 3.Yantai Key Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, Yantai, Shandong Province, China.; 4.Bohai rim Advanced Research Institute for Drug Discovery, Yantai, Shandong Province, China.; 5.School of Pharmacy, Yantai University, Yantai, Shandong Province, China. |
| 推荐引用方式 GB/T 7714 | Zhu, Runqi,Lang, Tianqun,Yin, Qi,et al. Nano drug delivery systems improve metastatic breast cancer therapy[J]. Medical review (Berlin, Germany),2021,1(2):244-274. |
| APA | Zhu, Runqi,Lang, Tianqun,Yin, Qi,&Li, Yaping.(2021).Nano drug delivery systems improve metastatic breast cancer therapy.Medical review (Berlin, Germany),1(2),244-274. |
| MLA | Zhu, Runqi,et al."Nano drug delivery systems improve metastatic breast cancer therapy".Medical review (Berlin, Germany) 1.2(2021):244-274. |
入库方式： OAI收割
来源：上海药物研究所
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