Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells
文献类型：期刊论文
| 作者 | Zhao, Dan3; Han, Hai-Hao3; Zhu, Ling3; Xu, Fang-Zhou3; Ma, Xing-Yu3; Li, Jia4 ; James, Tony D1,2; Zang, Yi4; He, Xiao-Peng3; Wang, Chengyun3
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| 刊名 | ACS applied bio materials
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| 出版日期 | 2021-09-20 |
| 卷号 | 4期号:9页码:7016-7024 |
| 关键词 | aggregation-induced emission (AIE) mitochondria photodynamic therapy (PDT) photosensitizer theranostic probe |
| ISSN号 | 2576-6422 |
| DOI | 10.1021/acsabm.1c00673 |
| 文献子类 | Article |
| 英文摘要 | With this research, we have developed two long-wavelength theranostic probes (DCMT and DCMC) with aggregation-induced emission (AIE)-based properties for image-guided photodynamic therapy (PDT) of hepatoma cells. Introduction of a triphenylamine or carbazole group to a dicyanomethylene-4H-pyran dye with long-wavelength fluorescence emission produces the AIE-based probes, which were subsequently modified with triphenyl-phosphonium cation for actively targeting the mitochondria of hepatoma cells. Solution-based experiments show that the probes exhibit a mixed photophysical mechanism of twisted-intramolecular charge transfer and AIE at different aggregation states. The molecular aggregation of the probes also leads to an enhanced ability for oxygen photosensitization, suggesting their potential for PDT of cancer cells. Our subsequent cell-based assays show that the probes localize in the mitochondria of hepatoma cells and the use of light leads to cell death through the intracellular production of reactive oxygen species. |
| 语种 | 英语 |
| WOS记录号 | MEDLINE:35006934 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309294]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.Department of Chemistry, University of Bath, Bath BA2 7AY, U.K.; 2.School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China. 3.Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.; 4.National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Road, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Zhao, Dan,Han, Hai-Hao,Zhu, Ling,et al. Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells[J]. ACS applied bio materials,2021,4(9):7016-7024. |
| APA | Zhao, Dan.,Han, Hai-Hao.,Zhu, Ling.,Xu, Fang-Zhou.,Ma, Xing-Yu.,...&Wang, Chengyun.(2021).Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells.ACS applied bio materials,4(9),7016-7024. |
| MLA | Zhao, Dan,et al."Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells".ACS applied bio materials 4.9(2021):7016-7024. |
入库方式： OAI收割
来源：上海药物研究所
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