Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic
文献类型：期刊论文
| 作者 | Zeng, Jinfeng10,11; Du, Fanshu9; Xiao, Linna8; Sun, Honglei9; Lu, Lu7; Lei, Weipan8; Zheng, Jialu10,11; Wang, Lu9; Shu, Sicheng9; Li, Yudong9 |
| 刊名 | JOURNAL OF VIROLOGY
 |
| 出版日期 | 2024-02-15 |
| 页码 | 18 |
| ISSN号 | 0022-538X |
| 关键词 | avian influenza virus (AIV) genesis spread bird migration |
| DOI | 10.1128/jvi.01401-23 |
| 通讯作者 | Du, Xiangjun(duxj9@mail.sysu.edu.cn) ; Pu, Juan(pujuan@cau.edu.cn) |
| 英文摘要 | Since 2020, clade 2.3.4.4b highly pathogenic avian influenza H5N8 and H5N1 viruses have swept through continents, posing serious threats to the world. Through comprehensive analyses of epidemiological, genetic, and bird migration data, we found that the dominant genotype replacement of the H5N8 viruses in 2020 contributed to the H5N1 outbreak in the 2021/2022 wave. The 2020 outbreak of the H5N8 G1 genotype instead of the G0 genotype produced reassortment opportunities and led to the emergence of a new H5N1 virus with G1's HA and MP genes. Despite extensive reassortments in the 2021/2022 wave, the H5N1 virus retained the HA and MP genes, causing a significant outbreak in Europe and North America. Furtherly, through the wild bird migration flyways investigation, we found that the temporal-spatial coincidence between the outbreak of the H5N8 G1 virus and the bird autumn migration may have expanded the H5 viral spread, which may be one of the main drivers of the emergence of the 2020-2022 H5 panzootic.IMPORTANCESince 2020, highly pathogenic avian influenza (HPAI) H5 subtype variants of clade 2.3.4.4b have spread across continents, posing unprecedented threats globally. However, the factors promoting the genesis and spread of H5 HPAI viruses remain unclear. Here, we found that the spatiotemporal genotype replacement of H5N8 HPAI viruses contributed to the emergence of the H5N1 variant that caused the 2021/2022 panzootic, and the viral evolution in poultry of Egypt and surrounding area and autumn bird migration from the Russia-Kazakhstan region to Europe are important drivers of the emergence of the 2020-2022 H5 panzootic. These findings provide important targets for early warning and could help control the current and future HPAI epidemics. Since 2020, highly pathogenic avian influenza (HPAI) H5 subtype variants of clade 2.3.4.4b have spread across continents, posing unprecedented threats globally. However, the factors promoting the genesis and spread of H5 HPAI viruses remain unclear. Here, we found that the spatiotemporal genotype replacement of H5N8 HPAI viruses contributed to the emergence of the H5N1 variant that caused the 2021/2022 panzootic, and the viral evolution in poultry of Egypt and surrounding area and autumn bird migration from the Russia-Kazakhstan region to Europe are important drivers of the emergence of the 2020-2022 H5 panzootic. These findings provide important targets for early warning and could help control the current and future HPAI epidemics. |
| WOS关键词 | EVOLUTION ; SPREAD |
| 资助项目 | MOST | National Natural Science Foundation of China (NSFC) |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| 出版者 | AMER SOC MICROBIOLOGY |
| WOS记录号 | WOS:001162932500001 |
| 资助机构 | MOST | National Natural Science Foundation of China (NSFC) |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/202868]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Du, Xiangjun; Pu, Juan |
| 作者单位 | 1.Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou, Peoples R China 2.Chinese Acad Med Sci CAMS, Peking Union Med Coll PUMC, Natl Hlth Commiss Key Lab Syst Biol Pathogens, Inst Pathogen Biol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Microbiol ogy, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 4.Natl Inst Viral Dis Control & Prevent, Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China 5.China Agr Univ, Coll Land Sci & Technol, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, Beijing, Peoples R China 7.Univ Edinburgh, Roslin Inst, Edinburgh, Scotland 8.Beijing Normal Univ, Coll Life Sci, Demonstrat Ctr Expt Life Sci & Biotechnol Educ, Key Lab Biodivers Sci & Ecol Engn, Beijing, Peoples R China 9.China Agr Univ, Natl Key Lab Vet Publ Hlth & Safety, Key Lab Prevent & Control Avian Influenza & Other, Minist Agr & Rural Affairs,Coll Vet Med, Beijing, Peoples R China 10.Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen Campus, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Jinfeng,Du, Fanshu,Xiao, Linna,et al. Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic[J]. JOURNAL OF VIROLOGY,2024:18. |
| APA | Zeng, Jinfeng.,Du, Fanshu.,Xiao, Linna.,Sun, Honglei.,Lu, Lu.,...&Pu, Juan.(2024).Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic.JOURNAL OF VIROLOGY,18. |
| MLA | Zeng, Jinfeng,et al."Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic".JOURNAL OF VIROLOGY (2024):18. |
入库方式： OAI收割
来源：地理科学与资源研究所
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